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学科主题: 物理化学
题名: Apoferritin-camouflaged Pt nanoparticles: surface effects on cellular uptake and cytotoxicity
作者: Liu, Xiangyou1, 2, 3;  Wei, Wei4;  Wang, Chunlei5;  Yue, Hua4;  Ma, Ding1;  Zhu, Cheng1;  Ma, Guanghui4;  Du, Yuguang2
通讯作者: MaD
刊名: JOURNAL OF MATERIALS CHEMISTRY
发表日期: 2011
DOI: 10.1039/c1jm10575b
卷: 21, 期:20, 页:7105-7110
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1805
产权排名: 1,1
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Chemistry, Physical ;  Materials Science, Multidisciplinary
摘要: Apoferritin-camouflaged Pt nanoparticles: surface effects on cellular uptake and cytotoxicity
研究领域[WOS]: Chemistry ;  Materials Science
英文摘要: Apoferritin-encapsulated Pt nanoparticles (AFt-Pt) were bio-mimetically prepared by an in situ reduction method in the unique 8 nm spherical cage of apoferritin. The average size of AFt-Pt was 4.3 +/- 0.9 nm. The spherical structure of apoferritin remained intact after loading Pt particles in its cavity. Apoferritin coating increased the amount of Pt internalized in HepG2 cells by about three times via receptor-mediated endocytosis. AFt-Pt showed greatly improved biocompatibility compared with polyvinylpyrrolidone stabilized Pt nanoparticles (PVP-Pt). More than 80% of cells survived after treatment with 100 mM AFt-Pt for 48 h. By camouflaging the particles with a protein corona, apoferritin conferred a cell-recognizable identity to the particles, which strikingly ameliorated the bio-effects of the nanoparticles.
关键词[WOS]: HORSE SPLEEN APOFERRITIN ;  PLATINUM NANOPARTICLE ;  PROTEIN CAGES ;  IRON RELEASE ;  FERRITIN ;  CELLS ;  BIOCOMPATIBILITY ;  LIVER
语种: 英语
WOS记录号: WOS:000290167200010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115526
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
5.Dalian Univ Technol, Sch Chem Engn, Carbon Res Lab, Dalian 116024, Peoples R China

Recommended Citation:
Liu, Xiangyou,Wei, Wei,Wang, Chunlei,et al. Apoferritin-camouflaged Pt nanoparticles: surface effects on cellular uptake and cytotoxicity[J]. JOURNAL OF MATERIALS CHEMISTRY,2011,21(20):7105-7110.
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