DICP OpenIR
Subject Area物理化学
Induction of apoptosis in human acute leukemia HL-60 cells by oligochitosan through extrinsic and intrinsic pathway
Dou, Jiangli1,2; Ma, Pan1,2; Xiong, Chuannan1; Tan, Chengyu3; Du, Yuguang1; Du YG(杜昱光)
KeywordOligochitosan Hl-60 Bax/bcl-2 Fas/fadd P21 Galectin-9
Source PublicationCARBOHYDRATE POLYMERS
2011-08-01
ISSN0144-8617
DOI10.1016/j.carbpol.2011.03.008
Volume86Issue:1Pages:19-24
Indexed BySCI
SubtypeArticle
Department18
Funding Project1805
Contribution Rank1,1
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS Research AreaChemistry ; Polymer Science
WOS KeywordCYCLE ARREST ; CHITOSAN OLIGOSACCHARIDES ; DNA-DAMAGE ; ACTIVATION ; GALECTIN-9 ; STRESS
AbstractInduction of apoptosis in human acute leukemia HL-60 cells by oligochitosan through extrinsic and intrinsic pathway; The underlying cellular and molecular mechanism about oligochitosan induced HL-60 cell apoptosis remained unknown. In the present study, we found oligochitosan treated HL-60 cells showed enhanced cleavage of poly (ADP-Ribose) polymerase PARP and p21 expression, accompanied with G0/G1 cell cycle arrest. After treatment with oligochitosan, the pro-apoptotic molecules Fas. FADD and Bax were up-regulated whereas anti-apoptotic Bcl-2 expression in HL-60 cells was significantly decreased. Furthermore, galectin-9 mRNA expression was increased in the presence of oligochitosan. We thus over-expressed galectin-9S or galectin-9L and found galectin-9 could significantly increase the oligochitosan induced apoptotic rate of HL-60 cells. Collectively, our data demonstrated that oligochitosan might regulate cell cycle progression and induce HL-60 cell apoptosis through both extrinsic and intrinsic pathways. (C) 2011 Elsevier Ltd. All rights reserved.
Language英语
WOS IDWOS:000293114900002
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/115527
Collection中国科学院大连化学物理研究所
Corresponding AuthorDu YG(杜昱光)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Dalian 116023, Peoples R China
3.Dalian Ocean Univ, Coll Ocean Environm Engn, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Dou, Jiangli,Ma, Pan,Xiong, Chuannan,et al. Induction of apoptosis in human acute leukemia HL-60 cells by oligochitosan through extrinsic and intrinsic pathway[J]. CARBOHYDRATE POLYMERS,2011,86(1):19-24.
APA Dou, Jiangli,Ma, Pan,Xiong, Chuannan,Tan, Chengyu,Du, Yuguang,&杜昱光.(2011).Induction of apoptosis in human acute leukemia HL-60 cells by oligochitosan through extrinsic and intrinsic pathway.CARBOHYDRATE POLYMERS,86(1),19-24.
MLA Dou, Jiangli,et al."Induction of apoptosis in human acute leukemia HL-60 cells by oligochitosan through extrinsic and intrinsic pathway".CARBOHYDRATE POLYMERS 86.1(2011):19-24.
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