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学科主题: 物理化学
题名: Induction of apoptosis in human acute leukemia HL-60 cells by oligochitosan through extrinsic and intrinsic pathway
作者: Dou, Jiangli1, 2;  Ma, Pan1, 2;  Xiong, Chuannan1;  Tan, Chengyu3;  Du, Yuguang1
通讯作者: 杜昱光
关键词: Oligochitosan ;  HL-60 ;  Bax/Bcl-2 ;  Fas/FADD ;  p21 ;  Galectin-9
刊名: CARBOHYDRATE POLYMERS
发表日期: 2011-08-01
DOI: 10.1016/j.carbpol.2011.03.008
卷: 86, 期:1, 页:19-24
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1805
产权排名: 1,1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Applied ;  Chemistry, Organic ;  Polymer Science
摘要: Induction of apoptosis in human acute leukemia HL-60 cells by oligochitosan through extrinsic and intrinsic pathway
研究领域[WOS]: Chemistry ;  Polymer Science
英文摘要: The underlying cellular and molecular mechanism about oligochitosan induced HL-60 cell apoptosis remained unknown. In the present study, we found oligochitosan treated HL-60 cells showed enhanced cleavage of poly (ADP-Ribose) polymerase PARP and p21 expression, accompanied with G0/G1 cell cycle arrest. After treatment with oligochitosan, the pro-apoptotic molecules Fas. FADD and Bax were up-regulated whereas anti-apoptotic Bcl-2 expression in HL-60 cells was significantly decreased. Furthermore, galectin-9 mRNA expression was increased in the presence of oligochitosan. We thus over-expressed galectin-9S or galectin-9L and found galectin-9 could significantly increase the oligochitosan induced apoptotic rate of HL-60 cells. Collectively, our data demonstrated that oligochitosan might regulate cell cycle progression and induce HL-60 cell apoptosis through both extrinsic and intrinsic pathways. (C) 2011 Elsevier Ltd. All rights reserved.
关键词[WOS]: CYCLE ARREST ;  CHITOSAN OLIGOSACCHARIDES ;  DNA-DAMAGE ;  ACTIVATION ;  GALECTIN-9 ;  STRESS
语种: 英语
WOS记录号: WOS:000293114900002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115527
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Dalian 116023, Peoples R China
3.Dalian Ocean Univ, Coll Ocean Environm Engn, Dalian 116023, Peoples R China

Recommended Citation:
Dou, Jiangli,Ma, Pan,Xiong, Chuannan,et al. Induction of apoptosis in human acute leukemia HL-60 cells by oligochitosan through extrinsic and intrinsic pathway[J]. CARBOHYDRATE POLYMERS,2011,86(1):19-24.
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