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学科主题物理化学
Synthesis of 1,2,3-triazole moiety-containing NAD analogs and their potential as redox cofactors
Hou, Shuhua1,2; Liu, Wujun1; Ji, Debin1,2; Wang, Qian1; Zhao, Zongbao Kent1,3; Zhao ZB(赵宗保)
关键词Nad Analogs Malic Enzyme Alcohol Dehydrogenase Promiscuity
刊名TETRAHEDRON LETTERS
2011-11-02
ISSN待补充
DOI10.1016/j.tetlet.2011.08.152
52期:44页:5855-5857
收录类别SCI ; IC
文章类型Article
部门归属18
项目归属1816
产权排名1,1
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]CHEMICAL-SYNTHESIS ; DEHYDROGENASE ; COENZYMES ; EVOLUTION ; RIBOSE
英文摘要Synthesis of 1,2,3-triazole moiety-containing NAD analogs and their potential as redox cofactors; Thirteen 1,2,3-triazole moiety-containing NAD analogs were synthesized and evaluated as redox cofactors. Noticeable enzymatic activities were observed when these analogs were employed as cofactors for malic enzyme or alcohol dehydrogenase. Our results indicated that the natural NAD-dependent oxidoreductases possessed flexible NAD binding pockets. (C) 2011 Elsevier Ltd. All rights reserved.
语种英语
WOS记录号WOS:000296168300033
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/115573
专题中国科学院大连化学物理研究所
通讯作者Zhao ZB(赵宗保)
作者单位1.CAS, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
3.Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China
推荐引用方式
GB/T 7714
Hou, Shuhua,Liu, Wujun,Ji, Debin,et al. Synthesis of 1,2,3-triazole moiety-containing NAD analogs and their potential as redox cofactors[J]. TETRAHEDRON LETTERS,2011,52(44):5855-5857.
APA Hou, Shuhua,Liu, Wujun,Ji, Debin,Wang, Qian,Zhao, Zongbao Kent,&赵宗保.(2011).Synthesis of 1,2,3-triazole moiety-containing NAD analogs and their potential as redox cofactors.TETRAHEDRON LETTERS,52(44),5855-5857.
MLA Hou, Shuhua,et al."Synthesis of 1,2,3-triazole moiety-containing NAD analogs and their potential as redox cofactors".TETRAHEDRON LETTERS 52.44(2011):5855-5857.
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