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学科主题: 物理化学
题名: Synthesis of 1,2,3-triazole moiety-containing NAD analogs and their potential as redox cofactors
作者: Hou, Shuhua1, 2;  Liu, Wujun1;  Ji, Debin1, 2;  Wang, Qian1;  Zhao, Zongbao Kent1, 3
通讯作者: 赵宗保
关键词: NAD analogs ;  Malic enzyme ;  Alcohol dehydrogenase ;  Promiscuity
刊名: TETRAHEDRON LETTERS
发表日期: 2011-11-02
DOI: 10.1016/j.tetlet.2011.08.152
卷: 52, 期:44, 页:5855-5857
收录类别: SCI ;  IC
文章类型: Article
部门归属: 18
项目归属: 1816
产权排名: 1,1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Organic
摘要: Synthesis of 1,2,3-triazole moiety-containing NAD analogs and their potential as redox cofactors
研究领域[WOS]: Chemistry
英文摘要: Thirteen 1,2,3-triazole moiety-containing NAD analogs were synthesized and evaluated as redox cofactors. Noticeable enzymatic activities were observed when these analogs were employed as cofactors for malic enzyme or alcohol dehydrogenase. Our results indicated that the natural NAD-dependent oxidoreductases possessed flexible NAD binding pockets. (C) 2011 Elsevier Ltd. All rights reserved.
关键词[WOS]: CHEMICAL-SYNTHESIS ;  DEHYDROGENASE ;  COENZYMES ;  EVOLUTION ;  RIBOSE
语种: 英语
WOS记录号: WOS:000296168300033
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115573
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.CAS, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
3.Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China

Recommended Citation:
Hou, Shuhua,Liu, Wujun,Ji, Debin,et al. Synthesis of 1,2,3-triazole moiety-containing NAD analogs and their potential as redox cofactors[J]. TETRAHEDRON LETTERS,2011,52(44):5855-5857.
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