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学科主题: 物理化学
题名: Efficient synthesis of triazole moiety-containing nucleotide analogs and their inhibitory effects on a malic enzyme
作者: Hou, Shuhua1, 2;  Liu, Wujun1;  Ji, Debin1, 2;  Zhao, Zongbao (Kent)1, 3
通讯作者: 赵宗保
关键词: Nucleotide analog ;  Enzyme inhibitor ;  Click chemistry ;  Synthesis ;  Malic enzyme
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2011-03-15
DOI: 10.1016/j.bmcl.2011.01.107
卷: 21, 期:6, 页:1667-1669
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1816
产权排名: 1,1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Chemistry, Medicinal ;  Chemistry, Organic
摘要: Efficient synthesis of triazole moiety-containing nucleotide analogs and their inhibitory effects on a malic enzyme
研究领域[WOS]: Pharmacology & Pharmacy ;  Chemistry
英文摘要: Eleven triazole moiety-containing nucleotide analogs were synthesized starting form tetra-O-acetylribose in 55-63% total yields. The synthesis involved two key steps, the lipase-mediated selective deacylation of 1-azido-2,3,5-tri-O-acetyl-beta-D-ribofuranoside and the Huisgen 1,3-dipolar cycloaddition between terminal alkynes and the 1-azido ribofuranoside derivative. These analogs showed inhibitory effects against a recombinant Escherichia coli NAD-dependent malic enzyme. (C) 2011 Elsevier Ltd. All rights reserved.
关键词[WOS]: ALKYNE 1,3-DIPOLAR CYCLOADDITION ;  CLICK-CHEMISTRY ;  REVERSE-TRANSCRIPTASE ;  IN-VITRO ;  NUCLEOSIDE ;  AZIDE ;  RIBAVIRIN ;  MIMICS ;  AGENTS ;  CHAIN
语种: 英语
WOS记录号: WOS:000288012800020
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115620
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.CAS, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
3.Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China

Recommended Citation:
Hou, Shuhua,Liu, Wujun,Ji, Debin,et al. Efficient synthesis of triazole moiety-containing nucleotide analogs and their inhibitory effects on a malic enzyme[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(6):1667-1669.
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