DICP OpenIR
Subject Area物理化学
Efficient synthesis of triazole moiety-containing nucleotide analogs and their inhibitory effects on a malic enzyme
Hou, Shuhua1,2; Liu, Wujun1; Ji, Debin1,2; Zhao, Zongbao (Kent)1,3; Zhao ZB(赵宗保)
KeywordNucleotide Analog Enzyme Inhibitor Click Chemistry Synthesis Malic Enzyme
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2011-03-15
ISSN待补充
DOI10.1016/j.bmcl.2011.01.107
Volume21Issue:6Pages:1667-1669
Indexed BySCI
SubtypeArticle
Department18
Funding Project1816
Contribution Rank1,1
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectChemistry, Medicinal ; Chemistry, Organic
WOS Research AreaPharmacology & Pharmacy ; Chemistry
WOS KeywordALKYNE 1,3-DIPOLAR CYCLOADDITION ; CLICK-CHEMISTRY ; REVERSE-TRANSCRIPTASE ; IN-VITRO ; NUCLEOSIDE ; AZIDE ; RIBAVIRIN ; MIMICS ; AGENTS ; CHAIN
AbstractEfficient synthesis of triazole moiety-containing nucleotide analogs and their inhibitory effects on a malic enzyme; Eleven triazole moiety-containing nucleotide analogs were synthesized starting form tetra-O-acetylribose in 55-63% total yields. The synthesis involved two key steps, the lipase-mediated selective deacylation of 1-azido-2,3,5-tri-O-acetyl-beta-D-ribofuranoside and the Huisgen 1,3-dipolar cycloaddition between terminal alkynes and the 1-azido ribofuranoside derivative. These analogs showed inhibitory effects against a recombinant Escherichia coli NAD-dependent malic enzyme. (C) 2011 Elsevier Ltd. All rights reserved.
Language英语
WOS IDWOS:000288012800020
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/115620
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhao ZB(赵宗保)
Affiliation1.CAS, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
3.Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Hou, Shuhua,Liu, Wujun,Ji, Debin,et al. Efficient synthesis of triazole moiety-containing nucleotide analogs and their inhibitory effects on a malic enzyme[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(6):1667-1669.
APA Hou, Shuhua,Liu, Wujun,Ji, Debin,Zhao, Zongbao ,&赵宗保.(2011).Efficient synthesis of triazole moiety-containing nucleotide analogs and their inhibitory effects on a malic enzyme.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,21(6),1667-1669.
MLA Hou, Shuhua,et al."Efficient synthesis of triazole moiety-containing nucleotide analogs and their inhibitory effects on a malic enzyme".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21.6(2011):1667-1669.
Files in This Item:
File Name/Size DocType Version Access License
2011yF765p5jPh.pdf(280KB) 开放获取--Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Hou, Shuhua]'s Articles
[Liu, Wujun]'s Articles
[Ji, Debin]'s Articles
Baidu academic
Similar articles in Baidu academic
[Hou, Shuhua]'s Articles
[Liu, Wujun]'s Articles
[Ji, Debin]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Hou, Shuhua]'s Articles
[Liu, Wujun]'s Articles
[Ji, Debin]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.