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学科主题: 物理化学
题名: Large-scale N-glycoproteome map of rat brain tissue: Simultaneous characterization of insoluble and soluble protein fractions
作者: Qiao, Xiaoqiang1, 2, 3;  Tao, Dingyin1;  Qu, Yanyan1;  Sun, Liangliang1;  Gao, Liang1;  Zhang, Xiaodan1;  Liang, Zhen1;  Zhang, Lihua1;  Zhang, Yukui1
通讯作者: 张丽华
关键词: Glycoproteomics ;  Hydrazide chemistry ;  Insoluble and soluble protein fraction ;  Ionic liquid ;  N-glycoproteome ;  Rat brain
刊名: PROTEOMICS
发表日期: 2011-11-01
DOI: 10.1002/pmic.201000715
卷: 11, 期:21, 页:4274-4278
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1810
产权排名: 1,1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemical Research Methods ;  Biochemistry & Molecular Biology
摘要: Large-scale N-glycoproteome map of rat brain tissue: Simultaneous characterization of insoluble and soluble protein fractions
研究领域[WOS]: Biochemistry & Molecular Biology
英文摘要: The large-scale N-glycosylation analysis is critical for biomedical research, since a variety of diseases are found to be associated with glycoproteins. By a combination of glycoprotein analysis in insoluble protein fraction solubilized with 1% v/v 1-butyl-3-methylimidazolium tetrafluoroborate (BMIM BF(4)) and those in soluble fraction, a total number of 462 non-redundant N-glycoprotein groups, including 316 transmembrane glycoproteins, were successfully identified. Correspondingly, 849 unique N-glycosites were confidently recognized. The data set could provide a support for the further in-depth research of brain N-glycosylation, such as for the discovery of candidate drug targets and biomarkers.
关键词[WOS]: TITANIUM-DIOXIDE CHROMATOGRAPHY ;  MASS-SPECTROMETRY ;  MEMBRANE PROTEOME ;  LINKED GLYCOPROTEINS ;  SELECTIVE ENRICHMENT ;  LC-MS/MS ;  IN-VIVO ;  IDENTIFICATION ;  CANCER ;  QUANTIFICATION
语种: 英语
WOS记录号: WOS:000297223200015
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115643
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China
2.Hebei Univ, Coll Pharmaceut Sci, Baoding, Peoples R China
3.Hebei Univ, Key Lab Pharmaceut Qual Control Hebei Prov, Baoding, Peoples R China

Recommended Citation:
Qiao, Xiaoqiang,Tao, Dingyin,Qu, Yanyan,et al. Large-scale N-glycoproteome map of rat brain tissue: Simultaneous characterization of insoluble and soluble protein fractions[J]. PROTEOMICS,2011,11(21):4274-4278.
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