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学科主题: 物理化学
题名: A fully automated system with on-line micro solid-phase extraction combined with capillary liquid chromatography-tandem mass spectrometry for high throughput analysis of microcystins and nodularin-R in tap water and lake water
作者: Shan, Yuanhong1;  Shi, Xianzhe1;  Dou, Abo1;  Zou, Cunjie1;  He, Hongbing1;  Yang, Qin1;  Zhao, Sumin1;  Lu, Xin1;  Xu, Guowang1
通讯作者: 许国旺
关键词: Microcystins ;  Nodularin-R ;  On-line micro solid-phase extraction ;  Capillary liquid chromatography-mass spectrometry
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2011-04-01
DOI: 10.1016/j.chroma.2011.01.069
卷: 1218, 期:13, 页:1743-1748
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 1,1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
摘要: A fully automated system with on-line micro solid-phase extraction combined with capillary liquid chromatography-tandem mass spectrometry for high throughput analysis of microcystins and nodularin-R in tap water and lake water
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Microcystins and nodularins are cyclic peptide hepatotoxins and tumour promoters from cyanobacteria. The present study describes the development, validation and practical application of a fully automated analytical method based on on-line micro solid-phase extraction-capillary liquid chromatography-tandem mass spectrometry for the simultaneous determination of seven microcystins and nodularin-R in tap water and lake water. Aliquots of just 100 mu L of water samples are sufficient for the detection and quantification of all eight toxins. Selected reaction monitoring was used to obtain the highest sensitivity. Good linear calibrations were obtained for microcystins (50-2000 ng/L) and nodularin-R (25-1000 ng/L) in spiked tap water and lake water samples. Excellent interday and intraday repeatability were achieved for eight toxins with relative standard deviation less than 15.7% in three different concentrations. Acceptable recoveries were achieved in the three concentrations with both tap water matrix and lake water matrix and no significant matrix effect was found in tap water and lake water except for microcystin-RR. The limits of detection (signal to noise ratio = 3) of toxins were lower than 56.6 ng/L which is far below the 1 mu g/L defined by the World Health Organization provisional guideline for microcystin-LR. Finally, this method was successfully applied to lake water samples from Tai lake and proved to be useful for water quality monitoring. (C) 2011 Elsevier B.V. All rights reserved.
关键词[WOS]: CYANOBACTERIAL TOXINS ;  SUPPLEMENT PRODUCTS ;  SAMPLES ;  MICROEXTRACTION ;  BLOOMS ;  LR
语种: 英语
WOS记录号: WOS:000288837400007
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115665
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

Recommended Citation:
Shan, Yuanhong,Shi, Xianzhe,Dou, Abo,et al. A fully automated system with on-line micro solid-phase extraction combined with capillary liquid chromatography-tandem mass spectrometry for high throughput analysis of microcystins and nodularin-R in tap water and lake water[J]. JOURNAL OF CHROMATOGRAPHY A,2011,1218(13):1743-1748.
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