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学科主题: 物理化学
题名: Application of plasma lipidomics in studying the response of patients with essential hypertension to antihypertensive drug therapy
作者: Hu, Chunxiu2;  Kong, Hongwei2;  Qu, Fengxue3;  Li, Yong2;  Yu, Zhenqiu3;  Gao, Peng2;  Peng, Shuangqing1;  Xu, Guowang2
通讯作者: PengShuangqing ;  许国旺
刊名: MOLECULAR BIOSYSTEMS
发表日期: 2011
DOI: 10.1039/c1mb05342f
卷: 7, 期:12, 页:3271-3279
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 1,1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology
摘要: Application of plasma lipidomics in studying the response of patients with essential hypertension to antihypertensive drug therapy
研究领域[WOS]: Biochemistry & Molecular Biology
英文摘要: Hypertension is a key risk factor in the progression of cardiovascular disease (CVD). Dyslipidemia, a strong predictor of CVD, frequently coexists with hypertension. Therefore, the control of hypertension and dyslipidemia may help reduce CVD morbidity and mortality. In the present study, the therapeutic effects of antihypertensive agents on blood pressure control and plasma lipid metabolism were evaluated. The plasma lipid profiles of patients with treated (n = 25) or untreated (n = 30) essential hypertension as well as of subjects with normotension (n = 28) were analyzed using liquid chromatography mass spectrometry. Principal component analysis of the lipidomics data revealed distinct clusters among studied subjects across three human populations. Phosphatidylcholines and triacylglycerols (TG) dominated the pattern of hypertension-influenced plasma lipid metabolism. Discriminatory lipid metabolites were analyzed using one-way analysis of variance followed by a post hoc multiple comparison correction. TG lipid class was significantly increased by 49.0% (p < 0.001) in hypertensive vs. normotensive groups while tended to decrease (-21.2%, p = 0.054) in hypertensive patients after treatment. Total cholesteryl esters were significantly decreased by -16.9% (p < 0.001) in hypertensive patients after treatment. In particular, a large number of individual neutral lipid species were significantly elevated in hypertensive subjects but significantly decreased after treatment with antihypertensive agents. The present study applied, for the first time, a systems biology based lipidomics approach to investigate differentiation among plasma lipid metabolism of patients with treated/untreated essential hypertension and subjects with normotension. Our results demonstrate that antihypertensive medications to lower blood pressure of hypertensive patients to target levels produced moderate plasma lipid metabolism improvement of patients with hypertension.
关键词[WOS]: NORMAL BLOOD-PRESSURE ;  METABOLIC SYNDROME ;  INSULIN-RESISTANCE ;  MASS-SPECTROMETRY ;  CARDIOVASCULAR-DISEASE ;  SYSTOLIC HYPERTENSION ;  RISK-FACTORS ;  DYSLIPIDEMIA ;  PREVALENCE ;  OBESITY
语种: 英语
WOS记录号: WOS:000296648800010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115668
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Acad Mil Med Sci, Evaluat & Res Ctr Toxicol, Inst Dis Control & Prevent, Beijing 100071, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.Capital Univ Med Sci, Beijing Anzhen Hosp, Beijing 100029, Peoples R China

Recommended Citation:
Hu, Chunxiu,Kong, Hongwei,Qu, Fengxue,et al. Application of plasma lipidomics in studying the response of patients with essential hypertension to antihypertensive drug therapy[J]. MOLECULAR BIOSYSTEMS,2011,7(12):3271-3279.
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