DICP OpenIR
学科主题物理化学
Effect of the traditional Chinese medicine tongxinluo on endothelial dysfunction rats studied by using urinary metabonomics based on liquid chromatography-mass spectrometry
Dai, Weidong2; Wei, Cong1; Kong, Hongwei2; Jia, Zhenhua1; Han, Jianke1; Zhang, Fengxia2; Wu, Zeming2; Gu, Yan2; Chen, Shili2; Gu, Qun2; Lu, Xin2; Wu, Yiling1; Xu, Guowang2; WuYiling; Xu GW(许国旺)
关键词Metabonomics Urine Endothelial Dysfunction Lc-ms Tongxinluo Simvastatin
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2011-08-25
ISSN待补充
DOI10.1016/j.jpba.2011.04.020
56期:1页:86-92
收录类别SCI
文章类型Article
部门归属18
项目归属1808
产权排名1,1
WOS标题词Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
类目[WOS]Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]INDOXYL SULFATE ; OXIDATIVE STRESS ; UREMIC TOXIN ; P-CRESOL ; HPLC-MS ; CELLS ; ATHEROSCLEROSIS ; METABOLOMICS ; STRATEGY ; SYSTEMS
英文摘要Effect of the traditional Chinese medicine tongxinluo on endothelial dysfunction rats studied by using urinary metabonomics based on liquid chromatography-mass spectrometry; A urinary metabonomic method based on ultra-fast liquid chromatography coupled with ion trap-time of flight mass spectrometry (UFLC/MS-IT-TOF) was employed to study the preventive efficacy and the metabolic changes caused by simavastatin and the traditional Chinese medicine tongxinluo in endothelial dysfunction rats. Principal component analysis (PCA) was applied to study metabolic patterns of endothelial dysfunction rats and healthy control rats. 1-Methyladenosine, indoxyl sulfate, hippuric acid, riboflavin, coproporphyrin, and p-cresol glucuronide were identified as potential biomarkers, indicating that pathways of adenine, tryptophan, phenylalanine, riboflavin, and porphyrin metabolism were disturbed in endothelial dysfunction rats. Applications of simvastatin and tongxinluo to endothelial dysfunction rats improved endothelial function according to the results of histopathology and measurements of endothelin-1 and nitric oxide. Metabonomic studies suggested that tongxinluo prevents endothelial dysfunction by regulating multiple metabolic pathways to their normal state, whereas simvastatin only altered selected metabolic pathways. This research demonstrated that metabonomics is a powerful and promising tool for disease investigation and the efficacy evaluation of complex traditional Chinese medicines. (C) 2011 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000291913500012
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/115670
专题中国科学院大连化学物理研究所
通讯作者WuYiling; Xu GW(许国旺)
作者单位1.Integrat Tradit & Western Med Res Acad Hebei Prov, Shijiazhuang 050035, Hebei Province, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
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GB/T 7714
Dai, Weidong,Wei, Cong,Kong, Hongwei,et al. Effect of the traditional Chinese medicine tongxinluo on endothelial dysfunction rats studied by using urinary metabonomics based on liquid chromatography-mass spectrometry[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2011,56(1):86-92.
APA Dai, Weidong.,Wei, Cong.,Kong, Hongwei.,Jia, Zhenhua.,Han, Jianke.,...&许国旺.(2011).Effect of the traditional Chinese medicine tongxinluo on endothelial dysfunction rats studied by using urinary metabonomics based on liquid chromatography-mass spectrometry.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,56(1),86-92.
MLA Dai, Weidong,et al."Effect of the traditional Chinese medicine tongxinluo on endothelial dysfunction rats studied by using urinary metabonomics based on liquid chromatography-mass spectrometry".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 56.1(2011):86-92.
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