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学科主题: 物理化学
题名: Effect of the traditional Chinese medicine tongxinluo on endothelial dysfunction rats studied by using urinary metabonomics based on liquid chromatography-mass spectrometry
作者: Dai, Weidong2;  Wei, Cong1;  Kong, Hongwei2;  Jia, Zhenhua1;  Han, Jianke1;  Zhang, Fengxia2;  Wu, Zeming2;  Gu, Yan2;  Chen, Shili2;  Gu, Qun2;  Lu, Xin2;  Wu, Yiling1;  Xu, Guowang2
通讯作者: WuYiling ;  许国旺
关键词: Metabonomics ;  Urine ;  Endothelial dysfunction ;  LC-MS ;  Tongxinluo ;  Simvastatin
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2011-08-25
DOI: 10.1016/j.jpba.2011.04.020
卷: 56, 期:1, 页:86-92
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 1,1
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Analytical ;  Pharmacology & Pharmacy
摘要: Effect of the traditional Chinese medicine tongxinluo on endothelial dysfunction rats studied by using urinary metabonomics based on liquid chromatography-mass spectrometry
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: A urinary metabonomic method based on ultra-fast liquid chromatography coupled with ion trap-time of flight mass spectrometry (UFLC/MS-IT-TOF) was employed to study the preventive efficacy and the metabolic changes caused by simavastatin and the traditional Chinese medicine tongxinluo in endothelial dysfunction rats. Principal component analysis (PCA) was applied to study metabolic patterns of endothelial dysfunction rats and healthy control rats. 1-Methyladenosine, indoxyl sulfate, hippuric acid, riboflavin, coproporphyrin, and p-cresol glucuronide were identified as potential biomarkers, indicating that pathways of adenine, tryptophan, phenylalanine, riboflavin, and porphyrin metabolism were disturbed in endothelial dysfunction rats. Applications of simvastatin and tongxinluo to endothelial dysfunction rats improved endothelial function according to the results of histopathology and measurements of endothelin-1 and nitric oxide. Metabonomic studies suggested that tongxinluo prevents endothelial dysfunction by regulating multiple metabolic pathways to their normal state, whereas simvastatin only altered selected metabolic pathways. This research demonstrated that metabonomics is a powerful and promising tool for disease investigation and the efficacy evaluation of complex traditional Chinese medicines. (C) 2011 Elsevier B.V. All rights reserved.
关键词[WOS]: INDOXYL SULFATE ;  OXIDATIVE STRESS ;  UREMIC TOXIN ;  P-CRESOL ;  HPLC-MS ;  CELLS ;  ATHEROSCLEROSIS ;  METABOLOMICS ;  STRATEGY ;  SYSTEMS
语种: 英语
WOS记录号: WOS:000291913500012
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115670
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Integrat Tradit & Western Med Res Acad Hebei Prov, Shijiazhuang 050035, Hebei Province, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

Recommended Citation:
Dai, Weidong,Wei, Cong,Kong, Hongwei,et al. Effect of the traditional Chinese medicine tongxinluo on endothelial dysfunction rats studied by using urinary metabonomics based on liquid chromatography-mass spectrometry[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2011,56(1):86-92.
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