DICP OpenIR
Subject Area物理化学
Effect of the traditional Chinese medicine tongxinluo on endothelial dysfunction rats studied by using urinary metabonomics based on liquid chromatography-mass spectrometry
Dai, Weidong2; Wei, Cong1; Kong, Hongwei2; Jia, Zhenhua1; Han, Jianke1; Zhang, Fengxia2; Wu, Zeming2; Gu, Yan2; Chen, Shili2; Gu, Qun2; Lu, Xin2; Wu, Yiling1; Xu, Guowang2; WuYiling; Xu GW(许国旺)
KeywordMetabonomics Urine Endothelial Dysfunction Lc-ms Tongxinluo Simvastatin
Source PublicationJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2011-08-25
ISSN待补充
DOI10.1016/j.jpba.2011.04.020
Volume56Issue:1Pages:86-92
Indexed BySCI
SubtypeArticle
Department18
Funding Project1808
Contribution Rank1,1
WOS HeadingsScience & Technology ; Physical Sciences ; Life Sciences & Biomedicine
WOS SubjectChemistry, Analytical ; Pharmacology & Pharmacy
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS KeywordINDOXYL SULFATE ; OXIDATIVE STRESS ; UREMIC TOXIN ; P-CRESOL ; HPLC-MS ; CELLS ; ATHEROSCLEROSIS ; METABOLOMICS ; STRATEGY ; SYSTEMS
AbstractEffect of the traditional Chinese medicine tongxinluo on endothelial dysfunction rats studied by using urinary metabonomics based on liquid chromatography-mass spectrometry; A urinary metabonomic method based on ultra-fast liquid chromatography coupled with ion trap-time of flight mass spectrometry (UFLC/MS-IT-TOF) was employed to study the preventive efficacy and the metabolic changes caused by simavastatin and the traditional Chinese medicine tongxinluo in endothelial dysfunction rats. Principal component analysis (PCA) was applied to study metabolic patterns of endothelial dysfunction rats and healthy control rats. 1-Methyladenosine, indoxyl sulfate, hippuric acid, riboflavin, coproporphyrin, and p-cresol glucuronide were identified as potential biomarkers, indicating that pathways of adenine, tryptophan, phenylalanine, riboflavin, and porphyrin metabolism were disturbed in endothelial dysfunction rats. Applications of simvastatin and tongxinluo to endothelial dysfunction rats improved endothelial function according to the results of histopathology and measurements of endothelin-1 and nitric oxide. Metabonomic studies suggested that tongxinluo prevents endothelial dysfunction by regulating multiple metabolic pathways to their normal state, whereas simvastatin only altered selected metabolic pathways. This research demonstrated that metabonomics is a powerful and promising tool for disease investigation and the efficacy evaluation of complex traditional Chinese medicines. (C) 2011 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000291913500012
Citation statistics
Cited Times:44[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/115670
Collection中国科学院大连化学物理研究所
Corresponding AuthorWuYiling; Xu GW(许国旺)
Affiliation1.Integrat Tradit & Western Med Res Acad Hebei Prov, Shijiazhuang 050035, Hebei Province, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Dai, Weidong,Wei, Cong,Kong, Hongwei,et al. Effect of the traditional Chinese medicine tongxinluo on endothelial dysfunction rats studied by using urinary metabonomics based on liquid chromatography-mass spectrometry[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2011,56(1):86-92.
APA Dai, Weidong.,Wei, Cong.,Kong, Hongwei.,Jia, Zhenhua.,Han, Jianke.,...&许国旺.(2011).Effect of the traditional Chinese medicine tongxinluo on endothelial dysfunction rats studied by using urinary metabonomics based on liquid chromatography-mass spectrometry.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,56(1),86-92.
MLA Dai, Weidong,et al."Effect of the traditional Chinese medicine tongxinluo on endothelial dysfunction rats studied by using urinary metabonomics based on liquid chromatography-mass spectrometry".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 56.1(2011):86-92.
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