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学科主题: 物理化学
题名: Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats
作者: Hu, Chunxiu1, 2;  Wei, Heng3, 4;  Kong, Hongwei1, 3;  Bouwman, Jildau4, 5;  Gonzalez-Covarrubias, Vanessa2, 5;  van der Heijden, Rob2;  Reijmers, Theo H.2;  Bao, Xu6;  Verheij, Elwin R.3, 4;  Hankemeier, Thomas2, 5;  Xu, Guowang1, 3;  van der Greef, Jan2, 3, 4, 7;  Wang, Mei3, 7
通讯作者: 许国旺 ;  vanderGreefJan ;  WangMei
刊名: MOLECULAR BIOSYSTEMS
发表日期: 2011
DOI: 10.1039/c1mb05254c
卷: 7, 期:11, 页:3094-3103
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 1,1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology
摘要: Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats
研究领域[WOS]: Biochemistry & Molecular Biology
英文摘要: Although a number of animal experiments and clinical trials have investigated the effects of ginseng roots on diabetes, the relationship between their therapeutic effects on diabetes and the quality and the growth age of this herb have not yet been reported. This study systematically investigated the effects of 3- to 6-year-old ginseng roots on glycemic and plasma lipid control in a rat model of type 2 diabetes. Six groups of male Goto-Kakizaki (GK) rats received either metformin, 3- to 6-year-old ginseng roots, or no treatment. The treatments were administered twice daily for 9 weeks. A combined approach was used that involved applying liquid chromatography-mass spectrometry-based lipidomics, measuring biochemical parameters and profiling the components of ginseng roots of different ages. Compared to the untreated controls, treatment with 4- and 6-year-old ginseng roots significantly improved glucose disposal, and 5-year-old ginseng treatment significantly increased high density lipoprotein cholesterol. Treatment with 6-year-old ginseng significantly decreased total plasma triacylglyceride (TG) and very-low-density lipoprotein cholesterol and improved plasma glycated hemoglobin (HbA1c). In addition, treatment with 4- to 6-year-old ginseng influenced plasma lipidomics in diabetic GK rats by reducing TG lipid species. Metformin significantly reduced fasting blood glucose by 41% and reduced HbA1c by 11%, but showed no effects on the plasma lipid parameters. The present study demonstrates that ginseng roots show growth age-dependent therapeutic effects on hyperlipidemia and hyperglycemia in diabetic GK rats. These age-dependent effects may be linked with the variation in both the ratios and concentrations of specific bioactive ginsenosides in ginseng roots of different growth ages. This study introduced novel systems biology-based approaches for linking biological activities with potential active components in herbal mixtures.
关键词[WOS]: MOUSE MODEL ;  MELLITUS ;  MECHANISMS ;  THERAPY ;  RE ;  METFORMIN ;  DISEASE ;  ALPHA ;  MICE ;  IDENTIFICATION
语种: 英语
WOS记录号: WOS:000295844100018
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115675
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Leiden Univ, Leiden Amsterdam Ctr Drug Res, Div Analyt Biosci, NL-2333 CC Leiden, Netherlands
3.Sino Dutch Ctr Prevent & Personalized Med, NL-3700 AJ Zeist, Netherlands
4.TNO, Dept Earth Environm & Life Sci, NL-3700 AJ Zeist, Netherlands
5.Leiden Univ, Netherlands Metabol Ctr, NL-2333 CC Leiden, Netherlands
6.Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Minist Educ, W China Sch Pharm, Chengdu 610041, Peoples R China
7.SU BioMed, NL-3700 AJ Zeist, Netherlands

Recommended Citation:
Hu, Chunxiu,Wei, Heng,Kong, Hongwei,et al. Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats[J]. MOLECULAR BIOSYSTEMS,2011,7(11):3094-3103.
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