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学科主题: 物理化学
题名: Metabolomics study of diabetic retinopathy using gas chromatography-mass spectrometry: a comparison of stages and subtypes diagnosed by Western and Chinese medicine
作者: Li, Xiang2;  Luo, Xiangxia3;  Lu, Xin2;  Duan, Junguo1;  Xu, Guowang2
通讯作者: DuanJunguo ;  许国旺
刊名: MOLECULAR BIOSYSTEMS
发表日期: 2011
DOI: 10.1039/c0mb00341g
卷: 7, 期:7, 页:2228-2237
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 1,1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology
摘要: Metabolomics study of diabetic retinopathy using gas chromatography-mass spectrometry: a comparison of stages and subtypes diagnosed by Western and Chinese medicine
研究领域[WOS]: Biochemistry & Molecular Biology
英文摘要: Diabetic retinopathy (DR) is a serious microvascular syndrome of diabetes, and is one of the most frequent causes of blindness in the world. It has three progressive stages with complex metabolic deregulations in the holistic system of Western medicine. Chinese medicine classifies DR into two different syndrome types; integrating Western and Chinese medicine to treat DR is a validated therapeutic approach in China. In this research, the systemic metabolite change of DR was investigated from the viewpoint of both Western and Chinese medicine, using metabolomics based on gas chromatography-mass spectrometry. The data revealed both perspectives can reflect the metabolic patterns, development and differentiation of DR, and the data also had good correlation and complementarity in characterizing the process of DR. Potential biomarkers of DR based on the two perspectives indicated the alterative modes of metabolites and metabolic pathways in the disease, e. g. the disturbance in fatty acids, amino acids and glucose, etc. The results showed the usefulness and validity of combining both Western and Chinese medicine to study the subtypes of DR and the mechanisms involved.
关键词[WOS]: POLYUNSATURATED FATTY-ACIDS ;  SYSTEMS BIOLOGY ;  GLUCOSE ;  METABONOMICS ;  SEVERITY ;  DISEASE ;  CONTEXT
语种: 英语
WOS记录号: WOS:000291559900015
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115678
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chengdu Univ Tradit Chinese Med, Teaching Hosp, Chengdu 610075, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.Gansu Prov Hosp, Dept Ophthalmol, Lanzhou 73005, Peoples R China

Recommended Citation:
Li, Xiang,Luo, Xiangxia,Lu, Xin,et al. Metabolomics study of diabetic retinopathy using gas chromatography-mass spectrometry: a comparison of stages and subtypes diagnosed by Western and Chinese medicine[J]. MOLECULAR BIOSYSTEMS,2011,7(7):2228-2237.
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