DICP OpenIR
Subject Area物理化学
Metabolomics study of diabetic retinopathy using gas chromatography-mass spectrometry: a comparison of stages and subtypes diagnosed by Western and Chinese medicine
Li, Xiang2; Luo, Xiangxia3; Lu, Xin2; Duan, Junguo1; Xu, Guowang2; DuanJunguo; Xu GW(许国旺)
Source PublicationMOLECULAR BIOSYSTEMS
2011
ISSN待补充
DOI10.1039/c0mb00341g
Volume7Issue:7Pages:2228-2237
Indexed BySCI
SubtypeArticle
Department18
Funding Project1808
Contribution Rank1,1
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemistry & Molecular Biology
WOS Research AreaBiochemistry & Molecular Biology
WOS KeywordPOLYUNSATURATED FATTY-ACIDS ; SYSTEMS BIOLOGY ; GLUCOSE ; METABONOMICS ; SEVERITY ; DISEASE ; CONTEXT
AbstractMetabolomics study of diabetic retinopathy using gas chromatography-mass spectrometry: a comparison of stages and subtypes diagnosed by Western and Chinese medicine; Diabetic retinopathy (DR) is a serious microvascular syndrome of diabetes, and is one of the most frequent causes of blindness in the world. It has three progressive stages with complex metabolic deregulations in the holistic system of Western medicine. Chinese medicine classifies DR into two different syndrome types; integrating Western and Chinese medicine to treat DR is a validated therapeutic approach in China. In this research, the systemic metabolite change of DR was investigated from the viewpoint of both Western and Chinese medicine, using metabolomics based on gas chromatography-mass spectrometry. The data revealed both perspectives can reflect the metabolic patterns, development and differentiation of DR, and the data also had good correlation and complementarity in characterizing the process of DR. Potential biomarkers of DR based on the two perspectives indicated the alterative modes of metabolites and metabolic pathways in the disease, e. g. the disturbance in fatty acids, amino acids and glucose, etc. The results showed the usefulness and validity of combining both Western and Chinese medicine to study the subtypes of DR and the mechanisms involved.
Language英语
WOS IDWOS:000291559900015
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/115678
Collection中国科学院大连化学物理研究所
Corresponding AuthorDuanJunguo; Xu GW(许国旺)
Affiliation1.Chengdu Univ Tradit Chinese Med, Teaching Hosp, Chengdu 610075, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.Gansu Prov Hosp, Dept Ophthalmol, Lanzhou 73005, Peoples R China
Recommended Citation
GB/T 7714
Li, Xiang,Luo, Xiangxia,Lu, Xin,et al. Metabolomics study of diabetic retinopathy using gas chromatography-mass spectrometry: a comparison of stages and subtypes diagnosed by Western and Chinese medicine[J]. MOLECULAR BIOSYSTEMS,2011,7(7):2228-2237.
APA Li, Xiang.,Luo, Xiangxia.,Lu, Xin.,Duan, Junguo.,Xu, Guowang.,...&许国旺.(2011).Metabolomics study of diabetic retinopathy using gas chromatography-mass spectrometry: a comparison of stages and subtypes diagnosed by Western and Chinese medicine.MOLECULAR BIOSYSTEMS,7(7),2228-2237.
MLA Li, Xiang,et al."Metabolomics study of diabetic retinopathy using gas chromatography-mass spectrometry: a comparison of stages and subtypes diagnosed by Western and Chinese medicine".MOLECULAR BIOSYSTEMS 7.7(2011):2228-2237.
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