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学科主题: 物理化学
题名: Plasma and Liver Lipidomics Response to an Intervention of Rimonabant in ApoE*3Leiden.CETP Transgenic Mice
作者: Hu, Chunxiu1, 2;  Wei, Heng3, 6;  van den Hoek, Anita M.5;  Wang, Mei3, 4;  van der Heijden, Rob2;  Spijksma, Gerwin2;  Reijmers, Theo H.2;  Bouwman, Jildau6, 7;  Wopereis, Suzan6;  Havekes, Louis M.5;  Verheij, Elwin6;  Hankemeier, Thomas2, 7;  Xu, Guowang1, 3;  van der Greef, Jan2, 3, 4, 6
通讯作者: 许国旺 ;  vanderGreefJan
刊名: PLOS ONE
发表日期: 2011-05-17
DOI: 10.1371/journal.pone.0019423
卷: 6, 期:5, 页:e19423
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 1,1
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
摘要: Plasma and Liver Lipidomics Response to an Intervention of Rimonabant in ApoE*3Leiden.CETP Transgenic Mice
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: Background: Lipids are known to play crucial roles in the development of life-style related risk factors such as obesity, dyslipoproteinemia, hypertension and diabetes. The first selective cannabinoid-1 receptor blocker rimonabant, an anorectic anti-obesity drug, was frequently used in conjunction with diet and exercise for patients with a body mass index greater than 30 kg/m(2) with associated risk factors such as type II diabetes and dyslipidaemia in the past. Less is known about the impact of this drug on the regulation of lipid metabolism in plasma and liver in the early stage of obesity.
关键词[WOS]: CHOLESTERYL ESTER TRANSFER ;  CARDIOVASCULAR RISK-FACTORS ;  INCREASES HDL-CHOLESTEROL ;  CB1 RECEPTOR ANTAGONIST ;  FREE FATTY-ACIDS ;  TRANSFER PROTEIN ;  AGGRAVATES ATHEROSCLEROSIS ;  OVERWEIGHT PATIENTS ;  METABOLIC SYNDROME ;  HEPATIC STEATOSIS
语种: 英语
WOS记录号: WOS:000290657500004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115681
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
2.Leiden Univ, Leiden Amsterdam Ctr Drug Res, Div Analyt Biosci, Leiden, Netherlands
3.Sino Dutch Ctr Prevent & Personalized Med, Zeist, Netherlands
4.SU BioMed, Zeist, Netherlands
5.TNO, Gaubius Lab, Leiden, Netherlands
6.TNO, Dept Earth Environm & Life Sci, NL-3700 AJ Zeist, Netherlands
7.Leiden Univ, Leiden Amsterdam Ctr Drug Res, Netherlands Metab Ctr, Leiden, Netherlands

Recommended Citation:
Hu, Chunxiu,Wei, Heng,van den Hoek, Anita M.,et al. Plasma and Liver Lipidomics Response to an Intervention of Rimonabant in ApoE*3Leiden.CETP Transgenic Mice[J]. PLOS ONE,2011,6(5):e19423.
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