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学科主题物理化学
Serum 27-nor-5 beta-Cholestane-3,7,12,24,25 Pentol Glucuronide Discovered by Metabolomics as Potential Diagnostic Biomarker for Epithelium Ovarian Cancer
Chen, Jing2; Zhang, Xiaoyan1; Cao, Rui3; Lu, Xin2; Zhao, Sumin2; Fekete, Agnes4; Huang, Qiang2; Schmitt-Kopplin, Philippe4; Wang, Yisheng1; Xu, Zhiliang2; Wan, Xiaoping5; Wu, Xiaohua6; Zhao, Naiqing7; Xu, Congjian1; Xu, Guowang2; XuCongjian; Xu GW(许国旺)
关键词Metabolomics Lc-ms Biomarker Discovery Epithelium Ovarian Cancer 27-nor-5 Beta-cholestane-3 7 12 24 25 Pentol Glucuronide
刊名JOURNAL OF PROTEOME RESEARCH
2011-05-01
ISSN待补充
DOI10.1021/pr200173q
10期:5页:2625-2632
收录类别SCI
文章类型Article
部门归属18
项目归属1808
产权排名1,1
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemical Research Methods
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]CHROMATOGRAPHY-MASS-SPECTROMETRY ; BILE ALCOHOL ; SPECTROSCOPIC DATA ; HEPATITIS-B ; METABONOMICS ; IDENTIFICATION ; METABOLITE ; FUTURE ; URINE ; EXPRESSION
英文摘要Serum 27-nor-5 beta-Cholestane-3,7,12,24,25 Pentol Glucuronide Discovered by Metabolomics as Potential Diagnostic Biomarker for Epithelium Ovarian Cancer; The aim of this study was to use a two steps strategy metabolomics to screen/identify and validate novel metabolic biomarker(s) for epithelial ovarian cancer (EOC). In the screening step, serum samples from 27 healthy women, 28 benign ovarian tumors, and 29 EOCs were analyzed by using LC-MS based nontargeted metabolomics. The three groups were separated with OSC filtered PLS-DA model, and six metabolites (27-nor-5 beta-cholestane-3,7,12,24,25 pentol glucuronide (CPG), phenylalanine, glycocholic acid, propionylcarnitine, Phe-Phe and Lyso PC (18:2)) were considered as potential biomarker candidates. In the validation step, the six metabolites were analyzed in targeted metabolomics by LC-selective ion monitoring mass spectrometry in another 685 serum samples with various clinical backgrounds. As a result, CPG was evaluated to be a potential biomarker and its content was elevated in EOC tissues compared with benign ovarian tumor tissues (p = 0.0005), Besides, CPG levels were found to be up-regulated in early stage EOC and in the three types of EOC histological types. Other variables such as nonovarian diseases, medicine consumotion, gynecological inflammations, and menopausal state did not interfere, in using CPG as diagnosis marker. CPG was found to be complementary to CA125. Our findings suggest that CPG can be considered a statistical relevant biomarker of EOC, ready for early stage detection.
语种英语
WOS记录号WOS:000290234800041
引用统计
被引频次:67[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/115683
专题中国科学院大连化学物理研究所
通讯作者XuCongjian; Xu GW(许国旺)
作者单位1.Fudan Univ, Obstet & Gynecol Hosp, Shanghai Med Sch, Inst Biomed Sci,Shanghai Key Lab Female Reprod En, Shanghai 200011, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.Dalian Med Univ, Dept Obstet & Gynecol Hosp, Dalian 116033, Peoples R China
4.Helmholtz Zentrum Muenchen, German Res Ctr Environm Hlth, Dept BioGeoChem & Analyt, Inst Ecol Chem, D-85764 Neuherberg, Germany
5.Shanghai Jiao Tong Univ, Sch Med, Int Peace Matern & Child Hlth Hosp, Shanghai 200030, Peoples R China
6.Fudan Univ, Dept Gynecol Oncol, Canc Hosp, Shanghai 200032, Peoples R China
7.Fudan Univ, Dept Biostat & Social Med, Sch Publ Hlth, Shanghai 200032, Peoples R China
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GB/T 7714
Chen, Jing,Zhang, Xiaoyan,Cao, Rui,et al. Serum 27-nor-5 beta-Cholestane-3,7,12,24,25 Pentol Glucuronide Discovered by Metabolomics as Potential Diagnostic Biomarker for Epithelium Ovarian Cancer[J]. JOURNAL OF PROTEOME RESEARCH,2011,10(5):2625-2632.
APA Chen, Jing.,Zhang, Xiaoyan.,Cao, Rui.,Lu, Xin.,Zhao, Sumin.,...&许国旺.(2011).Serum 27-nor-5 beta-Cholestane-3,7,12,24,25 Pentol Glucuronide Discovered by Metabolomics as Potential Diagnostic Biomarker for Epithelium Ovarian Cancer.JOURNAL OF PROTEOME RESEARCH,10(5),2625-2632.
MLA Chen, Jing,et al."Serum 27-nor-5 beta-Cholestane-3,7,12,24,25 Pentol Glucuronide Discovered by Metabolomics as Potential Diagnostic Biomarker for Epithelium Ovarian Cancer".JOURNAL OF PROTEOME RESEARCH 10.5(2011):2625-2632.
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