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学科主题: 物理化学
题名: Serum metabolic profiling and features of papillary thyroid carcinoma and nodular goiter
作者: Yao, Zhenzhen2;  Yin, Peiyuan1;  Su, Dongwei3;  Peng, Zhijun2;  Zhou, Lina1;  Ma, Long2;  Guo, Wei2;  Ma, Lie2;  Xu, Guowang1;  Shi, Junyi3;  Jiao, Binhua2
通讯作者: 许国旺 ;  ShiJunyi ;  JiaoBinhua
刊名: MOLECULAR BIOSYSTEMS
发表日期: 2011
DOI: 10.1039/c1mb05029j
卷: 7, 期:9, 页:2608-2614
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 2,2
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology
摘要: Serum metabolic profiling and features of papillary thyroid carcinoma and nodular goiter
研究领域[WOS]: Biochemistry & Molecular Biology
英文摘要: Thyroid carcinoma is a common endocrine malignancy worldwide, accounting for approximately 1% of all diagnosed cancers and about 91.5% of the malignancies of head and neck. However, differentiating malignant thyroid nodules from benign ones remains a diagnostic challenge. Thus, novel molecular markers that enable non-invasive diagnostics for malignant thyroid nodules are urgently needed. In the present study, a metabonomic investigation based on liquid chromatography-LTQ Orbitrap mass spectrometry was employed for serum metabolic profiling of 30 cases of papillary thyroid carcinomas (PTC), 80 cases of nodular goiters (benign thyroid nodules) and 30 cases of healthy controls. According to the results of multivariate statistical data analysis, the significantly changed metabolites among these three groups were defined. It was found that most of these metabolites decreased in the sera of both malignant and benign thyroid cases due to the increased metabolic rate, which is in accordance with clinical features. The major metabolic differences between benign and malignant nodules occurred in lipid metabolism. Especially, the content of 3-hydroxybutyric acid, an intermediate product of fatty acid metabolism, was much higher in the PTC group than that in the nodule goiter and control groups, indicating its potential as a diagnostic marker for PTC and nodular goiters. These results show that the serum metabolic profiling method is a powerful tool for distinguishing thyroid carcinoma from nodular goiter and healthy controls.
关键词[WOS]: FINE-NEEDLE-ASPIRATION ;  GLOBAL SYSTEMS BIOLOGY ;  MASS-SPECTROMETRY ;  GENE-EXPRESSION ;  CANCER ;  METABONOMICS ;  DIAGNOSIS ;  DISEASE ;  CARNITINE
语种: 英语
WOS记录号: WOS:000293648300010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115684
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China
3.Second Mil Med Univ, Dept Gen Surg 4, Changhai Hosp, Shanghai 200433, Peoples R China

Recommended Citation:
Yao, Zhenzhen,Yin, Peiyuan,Su, Dongwei,et al. Serum metabolic profiling and features of papillary thyroid carcinoma and nodular goiter[J]. MOLECULAR BIOSYSTEMS,2011,7(9):2608-2614.
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