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学科主题: 物理化学
题名: Therapeutic effect of Yunnan Baiyao on rheumatoid arthritis was partially due to regulating arachidonic acid metabolism in osteoblasts
作者: He, Hongbing1, 2;  Ren, Xiaobin2;  Wang, Xiyue1;  Shi, Xianzhe1;  Wang, Xiaolin1;  Ding, Zhongjuan2;  Gao, Peng1;  Xu, Guowang1
通讯作者: 高鹏 ;  许国旺
关键词: Rheumatoid arthritis ;  Arachidonic acid ;  Traditional Chinese Medicine ;  Osteoblast ;  Metabonomics
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2012-02-05
DOI: 10.1016/j.jpba.2011.10.019
卷: 59, 期:待补充, 页:130-137
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 1,1
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Analytical ;  Pharmacology & Pharmacy
摘要: Therapeutic effect of Yunnan Baiyao on rheumatoid arthritis was partially due to regulating arachidonic acid metabolism in osteoblasts
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: In order to explore the potential therapeutic effect of Yunnan Baiyao (YNB) on rheumatoid arthritis (RA), rat models were constructed and orally administrated with YNB or methotrexate (MTX) in parallel. Clinical physical, histological and biochemical parameters showed trivial therapeutic difference between YNB and MTX applications. Urine and serum metabonomics results indicated that many endogenous metabolites differentially changed among the rats receiving diverse therapeutic interventions. Among them, the fluctuation of arachidonic acid (AA) was thought to make sense. Thus, its relevant metabolites were subjected to quantitation by using osteoblasts treated by YNB in vitro. It was found that YNB extract of 20 mu g/mL could greatly activate the synthesis of intracellular prostaglandin E(2) and thromboxane B(2) in osteoblasts. Excretion of prostaglandin D(2) could be suppressed but not the thromboxane B(2). This study proved the efficacy of YNB on curing RA and its potential mechanism through modulating AA metabolism in osteoblasts to some extent. (C) 2011 Elsevier B.V. All rights reserved.
关键词[WOS]: COLLAGEN-INDUCED ARTHRITIS ;  MASS-SPECTROMETRY ;  SIGNALING PATHWAY ;  PROTEIN-KINASE ;  METHOTREXATE ;  METABONOMICS ;  RATS ;  SULFASALAZINE ;  METABOLOMICS ;  MECHANISMS
语种: 英语
WOS记录号: WOS:000297716500018
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115685
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Kunming Med Univ, Affiliated Stomatol Hosp, Kunming 650031, Peoples R China

Recommended Citation:
He, Hongbing,Ren, Xiaobin,Wang, Xiyue,et al. Therapeutic effect of Yunnan Baiyao on rheumatoid arthritis was partially due to regulating arachidonic acid metabolism in osteoblasts[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2012,59(待补充):130-137.
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