DICP OpenIR
Subject Area物理化学
Therapeutic effect of Yunnan Baiyao on rheumatoid arthritis was partially due to regulating arachidonic acid metabolism in osteoblasts
He, Hongbing1,2; Ren, Xiaobin2; Wang, Xiyue1; Shi, Xianzhe1; Wang, Xiaolin1; Ding, Zhongjuan2; Gao, Peng1; Xu, Guowang1; Gao P(高鹏); Xu GW(许国旺)
KeywordRheumatoid Arthritis Arachidonic Acid Traditional Chinese Medicine Osteoblast Metabonomics
Source PublicationJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2012-02-05
ISSN待补充
DOI10.1016/j.jpba.2011.10.019
Volume59Issue:待补充Pages:130-137
Indexed BySCI
SubtypeArticle
Department18
Funding Project1808
Contribution Rank1,1
WOS HeadingsScience & Technology ; Physical Sciences ; Life Sciences & Biomedicine
WOS SubjectChemistry, Analytical ; Pharmacology & Pharmacy
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS KeywordCOLLAGEN-INDUCED ARTHRITIS ; MASS-SPECTROMETRY ; SIGNALING PATHWAY ; PROTEIN-KINASE ; METHOTREXATE ; METABONOMICS ; RATS ; SULFASALAZINE ; METABOLOMICS ; MECHANISMS
AbstractTherapeutic effect of Yunnan Baiyao on rheumatoid arthritis was partially due to regulating arachidonic acid metabolism in osteoblasts; In order to explore the potential therapeutic effect of Yunnan Baiyao (YNB) on rheumatoid arthritis (RA), rat models were constructed and orally administrated with YNB or methotrexate (MTX) in parallel. Clinical physical, histological and biochemical parameters showed trivial therapeutic difference between YNB and MTX applications. Urine and serum metabonomics results indicated that many endogenous metabolites differentially changed among the rats receiving diverse therapeutic interventions. Among them, the fluctuation of arachidonic acid (AA) was thought to make sense. Thus, its relevant metabolites were subjected to quantitation by using osteoblasts treated by YNB in vitro. It was found that YNB extract of 20 mu g/mL could greatly activate the synthesis of intracellular prostaglandin E(2) and thromboxane B(2) in osteoblasts. Excretion of prostaglandin D(2) could be suppressed but not the thromboxane B(2). This study proved the efficacy of YNB on curing RA and its potential mechanism through modulating AA metabolism in osteoblasts to some extent. (C) 2011 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000297716500018
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/115685
Collection中国科学院大连化学物理研究所
Corresponding AuthorGao P(高鹏); Xu GW(许国旺)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Kunming Med Univ, Affiliated Stomatol Hosp, Kunming 650031, Peoples R China
Recommended Citation
GB/T 7714
He, Hongbing,Ren, Xiaobin,Wang, Xiyue,et al. Therapeutic effect of Yunnan Baiyao on rheumatoid arthritis was partially due to regulating arachidonic acid metabolism in osteoblasts[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2012,59(待补充):130-137.
APA He, Hongbing.,Ren, Xiaobin.,Wang, Xiyue.,Shi, Xianzhe.,Wang, Xiaolin.,...&许国旺.(2012).Therapeutic effect of Yunnan Baiyao on rheumatoid arthritis was partially due to regulating arachidonic acid metabolism in osteoblasts.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,59(待补充),130-137.
MLA He, Hongbing,et al."Therapeutic effect of Yunnan Baiyao on rheumatoid arthritis was partially due to regulating arachidonic acid metabolism in osteoblasts".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 59.待补充(2012):130-137.
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