中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
学科主题: 物理化学
题名: Promoting the formation and stabilization of human telomeric G-quadruplex DNA, inhibition of telomerase and cytotoxicity by phenanthroline derivatives
作者: Wang, Lihua1;  Wen, Ye1;  Liu, Jie1;  Zhou, Jun2;  Li, Can2;  Wei, Chunying1
通讯作者: 魏春英
刊名: ORGANIC & BIOMOLECULAR CHEMISTRY
发表日期: 2011
DOI: 10.1039/c0ob00961j
卷: 9, 期:8, 页:2648-2653
收录类别: SCI ;  IC
文章类型: Article
部门归属: 5
项目归属: 503
产权排名: 2,4
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Organic
摘要: Promoting the formation and stabilization of human telomeric G-quadruplex DNA, inhibition of telomerase and cytotoxicity by phenanthroline derivatives
研究领域[WOS]: Chemistry
英文摘要: Four new di-substituted phenanthroline-based compounds a-d have been designed and prepared, and they have been shown to induce the formation of anti-parallel structure of human telomeric G-quadruplex DNA by CD spectra. FRET assay indicates that the melting temperature increases (Delta T-m values) of G-quadruplex in buffer (pH 7.4) containing 100 mM NaCl are 31.6, 34.6, 17.8 and 32.6 degrees C for the compounds (1.0 mu M) a, b, c and d, respectively. Competitive FRET assay shows that the four compounds exhibit a high G-quadruplex DNA selectivity over duplex DNA. Three of the compounds are the potent telomerase inhibitors and HeLa cell proliferation inhibitors.
关键词[WOS]: INTRAMOLECULAR G-QUADRUPLEX ;  LIGANDS ;  COMPLEXES ;  RECOGNITION ;  BINDING ;  PROTOCOL ;  HYBRID ;  FORMS
语种: 英语
WOS记录号: WOS:000288904500013
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115744
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
2011jH4IduxtUa.pdf(1051KB)----开放获取--View 联系获取全文

作者单位: 1.Shanxi Univ, Inst Mol Sci, Key Lab Chem Biol & Mol Engn, Minist Educ, Taiyuan 030006, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, BState Key Lab Catalysis, Dalian 116023, Peoples R China

Recommended Citation:
Wang, Lihua,Wen, Ye,Liu, Jie,et al. Promoting the formation and stabilization of human telomeric G-quadruplex DNA, inhibition of telomerase and cytotoxicity by phenanthroline derivatives[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2011,9(8):2648-2653.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Wang, Lihua]'s Articles
 [Wen, Ye]'s Articles
 [Liu, Jie]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Wang, Lihua]‘s Articles
 [Wen, Ye]‘s Articles
 [Liu, Jie]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
文件名: 2011jH4IduxtUa.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace