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学科主题: 物理化学
题名: Bioactive Compounds from the Aerial Parts of Brachystemma calycinum and Structural Revision of an Octacyclopeptide
作者: Zhao, Jun2;  Zhou, Li-Li1;  Li, Xi3;  Xiao, Hong-Bin4;  Hou, Fan-Fan1;  Cheng, Yong-Xian2
通讯作者: Yong-XianCheng
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2011-06-01
DOI: 10.1021/np200048u
卷: 74, 期:6, 页:1392-1400
收录类别: SCI ;  IC
文章类型: Article
部门归属: 18
项目归属: 1804
产权排名: 4,4
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal ;  Pharmacology & Pharmacy
摘要: Bioactive Compounds from the Aerial Parts of Brachystemma calycinum and Structural Revision of an Octacyclopeptide
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy
英文摘要: Four new cyclic peptides, brachystemins F-I (1-4), and 11 known compounds were isolated from the aerial parts of Brachystemma calycinim. The absolute configurations of compounds 1-4 were assigned using Marfey's method. The structure of compound 5 was revised from cyclo-(Pro(1)-Phe(2)-Leu(3)-Ala(4)-Thr(5)-Pro(6)-Ala(7)-Gly(8)) to cyclo-(Pro(1)-Pro(2)-Ala(3)-Gly(4)-Leu(5)-Ala(6)-Thr(7)-Phe(8)) with QTOF/MS and X-ray diffraction analysis. The N-containing compounds were assessed for their inhibitory effects on the secretion of monocyte chemokine ligand 2 (CCL-2), interleukin 6 (IL-6), and collagen IV against high-glucose-stimulated mesangial cells. Compound 5 was evaluated for its effects on collagen I, reactive oxygen species (ROS), superoxide anion (O(2)(center dot-)) production, and cell viability in mesangial cells, and on nitric oxide (NO) production in macrophage cells.
关键词[WOS]: DIABETIC-NEPHROPATHY ;  INFLAMMATION ;  EXPRESSION ;  ALKALOIDS ;  COLLAGEN ;  GLUCOSE ;  ALPHA ;  BETA
语种: 英语
WOS记录号: WOS:000291920600007
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115829
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.So Med Univ, Nanfang Hosp, Div Nephrol, Key Lab Organ Failure Res,Educ Minist, Guangzhou 510515, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Zhao, Jun,Zhou, Li-Li,Li, Xi,et al. Bioactive Compounds from the Aerial Parts of Brachystemma calycinum and Structural Revision of an Octacyclopeptide[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(6):1392-1400.
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