DICP OpenIR
学科主题分析化学
Chromatographic Methodology and Technology for Developing TCM
Liang XM(梁鑫淼); Zhang XL(张秀莉); Xue XY(薛兴亚); Feng JT(丰加涛)
会议文集Program of the 2nd Annual Symposium on Chemical and Pharmaceutical Structure Analysis
会议名称the 2nd Annual Shanghai Symposium on Chemical and Pharmaceutical Structure Analysis
会议日期2011-4-13
2011
会议地点上海
其他题名中药研发色谱方法与技术
页码9-0
出版者待补充
出版地待补充
合作性质分会口头报告
部门归属1803
主办者CPSA组委会
英文摘要Chromatographic Methodology and Technology for Developing TCM Xinmiao Liang*, Xiuli Zhang, Xingya Xue, Jiatao Feng Dalian Institute of Chemical Physics, Chinese Academy of Sciences 457 Zhongshan Road, Dalian 116023, P. R. China E-mail: liangxm@dicp.ac.cns Presently, Traditional Chinese Medicine (TCM) is an important resource to treat many diseases, which has a long history in China, and is very complicated in chemical composition and pharmacology. Therefore, modernization of TCM is very necessary, including standardization, resourcing, quality control and research on chemical composition and pharmacology. “Multi-Component Chinese Medicine (MCCM)” represents a specific group of chemical composition produced from TCM according to a standardized separation process, which is hopefully to discover the chemical fundament of TCM’s pharmacology. The systematic research on MCCM is basing on modern separation and analytical techniques. In our group, a high-throughput preparation method has been developed in order to accelerate the pharmacological study of MCCM. The whole of TCMs were separated into a serious of small fractions containing several compounds by high-throughput preparative chromatography. Then these small fractions, what is called screening multi-components (SMCs), were screened by high-throughput screening (HTS). After biological screening, active multi-components were obtained and could be studied deeply further. This method will accelerate the process of explanation of the curative mechanism of TCMs, which simplifies the complex TCMs by concentrating on those interesting compounds from hundreds of thousands of compounds in TCMs. Standard libraries of SMCs are constructed, which will not only satisfy the need of TCMs, but also will speed up drug discovery by supplying persistent source for HTS. Two-dimensional liquid chromatography (2DLC) systems have developed for the characterization of SMCs and preparation of active compounds. Orthogonality and compatibility between the two-dimensional separations are key factors affecting the development of 2DLC. Based on the development of novel stationary phases, RP-HILIC 2DLC system and RP-RP 2DLC system were established. References [1] Guo ZM, Lei AW, Liang XM & Xu Q. Chem Comm, 4512-4514 (2006).. [2] Yanming Liu, Xingya Xue, Zhimou Guo, Qing Xu, Feifang Zhang, Xinmiao Liang. J. Chromatogr. A, 1208, 133–140 (2008) [3] Yanming Liu, Zhimou Guo, Yu Jin, Xingya Xue, Qing Xu, Feifang Zhang, Xinmiao Liang. J Chromatogr. A, 1206 153–159 (2008); Chromatographic Methodology and Technology for Developing TCM Xinmiao Liang*, Xiuli Zhang, Xingya Xue, Jiatao Feng Dalian Institute of Chemical Physics, Chinese Academy of Sciences 457 Zhongshan Road, Dalian 116023, P. R. China E-mail: liangxm@dicp.ac.cns Presently, Traditional Chinese Medicine (TCM) is an important resource to treat many diseases, which has a long history in China, and is very complicated in chemical composition and pharmacology. Therefore, modernization of TCM is very necessary, including standardization, resourcing, quality control and research on chemical composition and pharmacology. “Multi-Component Chinese Medicine (MCCM)” represents a specific group of chemical composition produced from TCM according to a standardized separation process, which is hopefully to discover the chemical fundament of TCM’s pharmacology. The systematic research on MCCM is basing on modern separation and analytical techniques. In our group, a high-throughput preparation method has been developed in order to accelerate the pharmacological study of MCCM. The whole of TCMs were separated into a serious of small fractions containing several compounds by high-throughput preparative chromatography. Then these small fractions, what is called screening multi-components (SMCs), were screened by high-throughput screening (HTS). After biological screening, active multi-components were obtained and could be studied deeply further. This method will accelerate the process of explanation of the curative mechanism of TCMs, which simplifies the complex TCMs by concentrating on those interesting compounds from hundreds of thousands of compounds in TCMs. Standard libraries of SMCs are constructed, which will not only satisfy the need of TCMs, but also will speed up drug discovery by supplying persistent source for HTS. Two-dimensional liquid chromatography (2DLC) systems have developed for the characterization of SMCs and preparation of active compounds. Orthogonality and compatibility between the two-dimensional separations are key factors affecting the development of 2DLC. Based on the development of novel stationary phases, RP-HILIC 2DLC system and RP-RP 2DLC system were established. References [1] Guo ZM, Lei AW, Liang XM & Xu Q. Chem Comm, 4512-4514 (2006).. [2] Yanming Liu, Xingya Xue, Zhimou Guo, Qing Xu, Feifang Zhang, Xinmiao Liang. J. Chromatogr. A, 1208, 133–140 (2008) [3] Yanming Liu, Zhimou Guo, Yu Jin, Xingya Xue, Qing Xu, Feifang Zhang, Xinmiao Liang. J Chromatogr. A, 1206 153–159 (2008)
文献类型会议论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/115940
专题中国科学院大连化学物理研究所
通讯作者Liang XM(梁鑫淼)
推荐引用方式
GB/T 7714
Liang XM,Zhang XL,Xue XY,et al. Chromatographic Methodology and Technology for Developing TCM[C]. 待补充:待补充,2011:9-0.
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