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学科主题: 分析化学
题名: The Application of Monolithic and Mesoporous Materials in Analysis of Biological Samples
作者: Zou HF(邹汉法)
会议文集: 2011 China-Japan-Korea Symposium of Analytical Science on Food, Environmental and Nano-Technology
会议名称: 2011 China-Japan-Korea Symposium of Analytical Science on Food, Environmental and Nano-Technology
会议日期: 2011-10-31
出版日期: 2011
会议地点: 济州
其他题名: 整体介孔材料在生物样品分析中的应用
通讯作者: 邹汉法
出版者: 待补充
出版地: 待补充
合作性质: 特邀报告
部门归属: 1809
主办者: 首尔女子大学
摘要: Sample preparation has been playing an important role in the analysis of complex samples. Mesoporous materials as the promising adsorbents have gained increasing research interest in sample preparations due to their desirable characteristics of high surface area, large pore volume, tunable mesoporous channels with well defined pore-size distribution, controllable wall composition, as well as modifiable surface properties. The recent advances of mesoporous materials in sample preparation with emphases on the size selective enrichment of peptides/proteins, specific capture of post-translational peptides/proteins and enzymatic reactor for protein digestion will be discussed. On the other hand, the organic inorganic hybrid monolithic columns have been attracting great attention in separation sciences. A one pot process for the preparation of organic silica hybrid capillary monolithic columns by concurrently using organic monomers and alkoxysilanes was developed. Different types of organic-silica hybrid capillary monolithic columns with hydrophobic, hydrophilic, ion exchange functionality and chiral selectors have been fabricated, respectively, by this one pot process using different types of organic monomers. Furthermore, the polyhedral oligomeric silsesquioxane reagents were proposed as the cross linkers for preparation of hybrid monolithic capillary column via thermal free radical copolymerization with different types of organic monomers. The synthesized hybrid monoliths possessed the merits of organic polymer-based monoliths and silica based monoliths with good mechanical and pH stabilities and high column efficiencies. The performances of these organic-silica monolithic columns were investigated by capillary liquid chromatography separation and micro-extraction of the biological samples.
英文摘要: Sample preparation has been playing an important role in the analysis of complex samples. Mesoporous materials as the promising adsorbents have gained increasing research interest in sample preparations due to their desirable characteristics of high surface area, large pore volume, tunable mesoporous channels with well defined pore-size distribution, controllable wall composition, as well as modifiable surface properties. The recent advances of mesoporous materials in sample preparation with emphases on the size selective enrichment of peptides/proteins, specific capture of post-translational peptides/proteins and enzymatic reactor for protein digestion will be discussed. On the other hand, the organic inorganic hybrid monolithic columns have been attracting great attention in separation sciences. A one pot process for the preparation of organic silica hybrid capillary monolithic columns by concurrently using organic monomers and alkoxysilanes was developed. Different types of organic-silica hybrid capillary monolithic columns with hydrophobic, hydrophilic, ion exchange functionality and chiral selectors have been fabricated, respectively, by this one pot process using different types of organic monomers. Furthermore, the polyhedral oligomeric silsesquioxane reagents were proposed as the cross linkers for preparation of hybrid monolithic capillary column via thermal free radical copolymerization with different types of organic monomers. The synthesized hybrid monoliths possessed the merits of organic polymer-based monoliths and silica based monoliths with good mechanical and pH stabilities and high column efficiencies. The performances of these organic-silica monolithic columns were investigated by capillary liquid chromatography separation and micro-extraction of the biological samples.
语种: 英语
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/115978
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Zou HF. The Application of Monolithic and Mesoporous Materials in Analysis of Biological Samples[C]. 见:2011 China-Japan-Korea Symposium of Analytical Science on Food, Environmental and Nano-Technology. 济州. 2011-10-31.
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