DICP OpenIR
Subject Area化学其他学科
Methodology and applications of HPLC MS based metabolomics in the exploration of biomarkers
Yin PY(尹沛源); Zhao XJ(赵欣捷); Lu X(路鑫); Xu GW(许国旺)
Source PublicationSino-German Frontiers of Science Symposium 2011
Conference NameSino-German Frontiers of Science Symposium 2011
Conference Date2011-4-27
2011
Conference Place柏林
Alternative Title基于液相色谱质谱的代谢组学方法在疾病标志物发现中的应用
Pages5-0
Publisher待补充
Publication Place待补充
Cooperation Status特邀报告
Department1808
Funding OrganizationAlexander von Humboldt Foundation
AbstractMetabonomics is an important platform of systems biology, which focuses on the dynamic metabolic changes in the organism. When applied to life science, metabonomics surveys provide great potential in the exploration of potential biomarkers, which could improve diagnosis and subsequent clinical outcome. Based on the chromatography/mass spectrometry analytical techniques, we have developed an integrated strategy for the metabonomic study of diseases. Firstly, we had set a standard for sample collection which may ensure the data quality for the whole study. Secondly, an effective method for the treatment of massive data was developed based on chemometrics and feature selection techniques. Thirdly, a method for the structure identification of unknown metabolites has also been established. The last part is the biological interpretation and validation of the potential biomarkers. In our group, the metabonomic platform had been applied to the study of cancer, diabetes 2 and other diseases. In this presentation, I would give an introduction of our metabonomic platform and its application on the study of cancer and diabetes.; Metabonomics is an important platform of systems biology, which focuses on the dynamic metabolic changes in the organism. When applied to life science, metabonomics surveys provide great potential in the exploration of potential biomarkers, which could improve diagnosis and subsequent clinical outcome. Based on the chromatography/mass spectrometry analytical techniques, we have developed an integrated strategy for the metabonomic study of diseases. Firstly, we had set a standard for sample collection which may ensure the data quality for the whole study. Secondly, an effective method for the treatment of massive data was developed based on chemometrics and feature selection techniques. Thirdly, a method for the structure identification of unknown metabolites has also been established. The last part is the biological interpretation and validation of the potential biomarkers. In our group, the metabonomic platform had been applied to the study of cancer, diabetes 2 and other diseases. In this presentation, I would give an introduction of our metabonomic platform and its application on the study of cancer and diabetes.
Document Type会议论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/116046
Collection中国科学院大连化学物理研究所
Corresponding AuthorXu GW(许国旺)
Recommended Citation
GB/T 7714
Yin PY,Zhao XJ,Lu X,et al. Methodology and applications of HPLC MS based metabolomics in the exploration of biomarkers[C]. 待补充:待补充,2011:5-0.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[尹沛源]'s Articles
[赵欣捷]'s Articles
[路鑫]'s Articles
Baidu academic
Similar articles in Baidu academic
[尹沛源]'s Articles
[赵欣捷]'s Articles
[路鑫]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[尹沛源]'s Articles
[赵欣捷]'s Articles
[路鑫]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.