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学科主题: 化学其他学科
题名: Methodology and applications of HPLC MS based metabolomics in the exploration of biomarkers
作者: Yin PY(尹沛源) ;  Zhao XJ(赵欣捷) ;  Lu X(路鑫) ;  Xu GW(许国旺)
会议文集: Sino-German Frontiers of Science Symposium 2011
会议名称: Sino-German Frontiers of Science Symposium 2011
会议日期: 2011-4-27
出版日期: 2011
会议地点: 柏林
其他题名: 基于液相色谱质谱的代谢组学方法在疾病标志物发现中的应用
通讯作者: 许国旺
出版者: 待补充
出版地: 待补充
合作性质: 特邀报告
部门归属: 1808
主办者: Alexander von Humboldt Foundation
摘要: Metabonomics is an important platform of systems biology, which focuses on the dynamic metabolic changes in the organism. When applied to life science, metabonomics surveys provide great potential in the exploration of potential biomarkers, which could improve diagnosis and subsequent clinical outcome. Based on the chromatography/mass spectrometry analytical techniques, we have developed an integrated strategy for the metabonomic study of diseases. Firstly, we had set a standard for sample collection which may ensure the data quality for the whole study. Secondly, an effective method for the treatment of massive data was developed based on chemometrics and feature selection techniques. Thirdly, a method for the structure identification of unknown metabolites has also been established. The last part is the biological interpretation and validation of the potential biomarkers. In our group, the metabonomic platform had been applied to the study of cancer, diabetes 2 and other diseases. In this presentation, I would give an introduction of our metabonomic platform and its application on the study of cancer and diabetes.
英文摘要: Metabonomics is an important platform of systems biology, which focuses on the dynamic metabolic changes in the organism. When applied to life science, metabonomics surveys provide great potential in the exploration of potential biomarkers, which could improve diagnosis and subsequent clinical outcome. Based on the chromatography/mass spectrometry analytical techniques, we have developed an integrated strategy for the metabonomic study of diseases. Firstly, we had set a standard for sample collection which may ensure the data quality for the whole study. Secondly, an effective method for the treatment of massive data was developed based on chemometrics and feature selection techniques. Thirdly, a method for the structure identification of unknown metabolites has also been established. The last part is the biological interpretation and validation of the potential biomarkers. In our group, the metabonomic platform had been applied to the study of cancer, diabetes 2 and other diseases. In this presentation, I would give an introduction of our metabonomic platform and its application on the study of cancer and diabetes.
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/116046
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Yin PY,Zhao XJ,Lu X,et al. Methodology and applications of HPLC MS based metabolomics in the exploration of biomarkers[C]. 见:Sino-German Frontiers of Science Symposium 2011. 柏林. 2011-4-27.
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