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学科主题化学其他学科
Methodology and applications of HPLC MS based metabolomics in the exploration of biomarkers
Yin PY(尹沛源); Zhao XJ(赵欣捷); Lu X(路鑫); Xu GW(许国旺)
会议文集Sino-German Frontiers of Science Symposium 2011
会议名称Sino-German Frontiers of Science Symposium 2011
会议日期2011-4-27
2011
会议地点柏林
其他题名基于液相色谱质谱的代谢组学方法在疾病标志物发现中的应用
页码5-0
出版者待补充
出版地待补充
合作性质特邀报告
部门归属1808
主办者Alexander von Humboldt Foundation
英文摘要Metabonomics is an important platform of systems biology, which focuses on the dynamic metabolic changes in the organism. When applied to life science, metabonomics surveys provide great potential in the exploration of potential biomarkers, which could improve diagnosis and subsequent clinical outcome. Based on the chromatography/mass spectrometry analytical techniques, we have developed an integrated strategy for the metabonomic study of diseases. Firstly, we had set a standard for sample collection which may ensure the data quality for the whole study. Secondly, an effective method for the treatment of massive data was developed based on chemometrics and feature selection techniques. Thirdly, a method for the structure identification of unknown metabolites has also been established. The last part is the biological interpretation and validation of the potential biomarkers. In our group, the metabonomic platform had been applied to the study of cancer, diabetes 2 and other diseases. In this presentation, I would give an introduction of our metabonomic platform and its application on the study of cancer and diabetes.; Metabonomics is an important platform of systems biology, which focuses on the dynamic metabolic changes in the organism. When applied to life science, metabonomics surveys provide great potential in the exploration of potential biomarkers, which could improve diagnosis and subsequent clinical outcome. Based on the chromatography/mass spectrometry analytical techniques, we have developed an integrated strategy for the metabonomic study of diseases. Firstly, we had set a standard for sample collection which may ensure the data quality for the whole study. Secondly, an effective method for the treatment of massive data was developed based on chemometrics and feature selection techniques. Thirdly, a method for the structure identification of unknown metabolites has also been established. The last part is the biological interpretation and validation of the potential biomarkers. In our group, the metabonomic platform had been applied to the study of cancer, diabetes 2 and other diseases. In this presentation, I would give an introduction of our metabonomic platform and its application on the study of cancer and diabetes.
文献类型会议论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/116046
专题中国科学院大连化学物理研究所
通讯作者Xu GW(许国旺)
推荐引用方式
GB/T 7714
Yin PY,Zhao XJ,Lu X,et al. Methodology and applications of HPLC MS based metabolomics in the exploration of biomarkers[C]. 待补充:待补充,2011:5-0.
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