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学科主题分析化学
Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats
Hu CX(胡春秀); HengWei; Kong HW(孔宏伟); JildauBouwman; TheoH.Reijmers; ElwinR.Verheij; ThomasHankemeier; JanvanderGreef; Wang M(王梅); Xu GW(许国旺)
会议文集Proceedings of HPLC2011
会议名称37th International Symposium on High Performance Liquid Phase Separations and Related Techniques
会议日期2011-10-8
2011
会议地点大连
页码107-0
出版者待补充
出版地待补充
合作性质分会口头报告
部门归属1808
主办者中国化学会色谱专业委员会
英文摘要Although a number of animal experiments and clinical trials have investigated the effects of ginseng roots on diabetes, the relationship between its therapeutic effects on diabetes and the quality and the growth age of this herb have not yet been reported. This study systematically investigated the effects of 3- to 6-y-old ginseng roots on glycemic and plasma lipid control in a rat model of type 2 diabetes. Six groups of male Goto-Kakizaki (GK) rats received either metformin, 3- to 6-y-old ginseng root, or no treatment. The treatments were administered twice daily for 9 weeks. A combined approach was used that involved applying liquid chromatography–mass spectrometry-based lipidomics, measuring biochemical parameters and profiling the components of ginseng roots of different ages. Compared to the untreated controls, treatment with 4- and 6-y-old ginseng roots significantly improved glucose disposal, and 5-y-old ginseng treatment significantly increased high density lipoprotein cholesterol. Treatment with 6-y-old ginseng significantly decreased total plasma triacylglyceride (TG) and very-low-density lipoprotein cholesterol and improved plasma glycated hemoglobin (HbA1c). In addition, treatment with 4- to 6-y-old ginseng influenced plasma lipidomics in diabetic GK rats by reducing TG lipid species. Metformin significantly reduced fasting blood glucose by 41% and reduced HbA1c by 11%, but showed no effects on the plasma lipid parameters. The present study demonstrates that ginseng roots show growth age-dependent therapeutic effects on hyperlipidemia and hyperglycemia in diabetic GK rats. These age-dependent effects may be linked with the variation in both the ratios and concentrations of specific bioactive ginsenosides in ginseng roots of different growth ages. This study introduced novel systems biology-based approaches for linking biological activities with potential active components in herbal mixtures.; Although a number of animal experiments and clinical trials have investigated the effects of ginseng roots on diabetes, the relationship between its therapeutic effects on diabetes and the quality and the growth age of this herb have not yet been reported. This study systematically investigated the effects of 3- to 6-y-old ginseng roots on glycemic and plasma lipid control in a rat model of type 2 diabetes. Six groups of male Goto-Kakizaki (GK) rats received either metformin, 3- to 6-y-old ginseng root, or no treatment. The treatments were administered twice daily for 9 weeks. A combined approach was used that involved applying liquid chromatography–mass spectrometry-based lipidomics, measuring biochemical parameters and profiling the components of ginseng roots of different ages. Compared to the untreated controls, treatment with 4- and 6-y-old ginseng roots significantly improved glucose disposal, and 5-y-old ginseng treatment significantly increased high density lipoprotein cholesterol. Treatment with 6-y-old ginseng significantly decreased total plasma triacylglyceride (TG) and very-low-density lipoprotein cholesterol and improved plasma glycated hemoglobin (HbA1c). In addition, treatment with 4- to 6-y-old ginseng influenced plasma lipidomics in diabetic GK rats by reducing TG lipid species. Metformin significantly reduced fasting blood glucose by 41% and reduced HbA1c by 11%, but showed no effects on the plasma lipid parameters. The present study demonstrates that ginseng roots show growth age-dependent therapeutic effects on hyperlipidemia and hyperglycemia in diabetic GK rats. These age-dependent effects may be linked with the variation in both the ratios and concentrations of specific bioactive ginsenosides in ginseng roots of different growth ages. This study introduced novel systems biology-based approaches for linking biological activities with potential active components in herbal mixtures.
文献类型会议论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/116060
专题中国科学院大连化学物理研究所
通讯作者Wang M(王梅); Xu GW(许国旺)
推荐引用方式
GB/T 7714
Hu CX,HengWei,Kong HW,et al. Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats[C]. 待补充:待补充,2011:107-0.
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