DICP OpenIR
Subject Area分析化学
Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats
Hu CX(胡春秀); HengWei; Kong HW(孔宏伟); JildauBouwman; TheoH.Reijmers; ElwinR.Verheij; ThomasHankemeier; JanvanderGreef; Wang M(王梅); Xu GW(许国旺)
Source PublicationProceedings of HPLC2011
Conference Name37th International Symposium on High Performance Liquid Phase Separations and Related Techniques
Conference Date2011-10-8
2011
Conference Place大连
Pages107-0
Publisher待补充
Publication Place待补充
Cooperation Status分会口头报告
Department1808
Funding Organization中国化学会色谱专业委员会
AbstractAlthough a number of animal experiments and clinical trials have investigated the effects of ginseng roots on diabetes, the relationship between its therapeutic effects on diabetes and the quality and the growth age of this herb have not yet been reported. This study systematically investigated the effects of 3- to 6-y-old ginseng roots on glycemic and plasma lipid control in a rat model of type 2 diabetes. Six groups of male Goto-Kakizaki (GK) rats received either metformin, 3- to 6-y-old ginseng root, or no treatment. The treatments were administered twice daily for 9 weeks. A combined approach was used that involved applying liquid chromatography–mass spectrometry-based lipidomics, measuring biochemical parameters and profiling the components of ginseng roots of different ages. Compared to the untreated controls, treatment with 4- and 6-y-old ginseng roots significantly improved glucose disposal, and 5-y-old ginseng treatment significantly increased high density lipoprotein cholesterol. Treatment with 6-y-old ginseng significantly decreased total plasma triacylglyceride (TG) and very-low-density lipoprotein cholesterol and improved plasma glycated hemoglobin (HbA1c). In addition, treatment with 4- to 6-y-old ginseng influenced plasma lipidomics in diabetic GK rats by reducing TG lipid species. Metformin significantly reduced fasting blood glucose by 41% and reduced HbA1c by 11%, but showed no effects on the plasma lipid parameters. The present study demonstrates that ginseng roots show growth age-dependent therapeutic effects on hyperlipidemia and hyperglycemia in diabetic GK rats. These age-dependent effects may be linked with the variation in both the ratios and concentrations of specific bioactive ginsenosides in ginseng roots of different growth ages. This study introduced novel systems biology-based approaches for linking biological activities with potential active components in herbal mixtures.; Although a number of animal experiments and clinical trials have investigated the effects of ginseng roots on diabetes, the relationship between its therapeutic effects on diabetes and the quality and the growth age of this herb have not yet been reported. This study systematically investigated the effects of 3- to 6-y-old ginseng roots on glycemic and plasma lipid control in a rat model of type 2 diabetes. Six groups of male Goto-Kakizaki (GK) rats received either metformin, 3- to 6-y-old ginseng root, or no treatment. The treatments were administered twice daily for 9 weeks. A combined approach was used that involved applying liquid chromatography–mass spectrometry-based lipidomics, measuring biochemical parameters and profiling the components of ginseng roots of different ages. Compared to the untreated controls, treatment with 4- and 6-y-old ginseng roots significantly improved glucose disposal, and 5-y-old ginseng treatment significantly increased high density lipoprotein cholesterol. Treatment with 6-y-old ginseng significantly decreased total plasma triacylglyceride (TG) and very-low-density lipoprotein cholesterol and improved plasma glycated hemoglobin (HbA1c). In addition, treatment with 4- to 6-y-old ginseng influenced plasma lipidomics in diabetic GK rats by reducing TG lipid species. Metformin significantly reduced fasting blood glucose by 41% and reduced HbA1c by 11%, but showed no effects on the plasma lipid parameters. The present study demonstrates that ginseng roots show growth age-dependent therapeutic effects on hyperlipidemia and hyperglycemia in diabetic GK rats. These age-dependent effects may be linked with the variation in both the ratios and concentrations of specific bioactive ginsenosides in ginseng roots of different growth ages. This study introduced novel systems biology-based approaches for linking biological activities with potential active components in herbal mixtures.
Document Type会议论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/116060
Collection中国科学院大连化学物理研究所
Corresponding AuthorWang M(王梅); Xu GW(许国旺)
Recommended Citation
GB/T 7714
Hu CX,HengWei,Kong HW,et al. Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats[C]. 待补充:待补充,2011:107-0.
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