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学科主题: 分析化学
题名: Development of off-line two dimensional liquid chromatography-mass
作者: Zhao SM(赵素敏) ;  Yang Q(杨芹) ;  Shi XZ(石先哲) ;  Lu X(路鑫) ;  Xu GW(许国旺)
会议文集: Proceeding of HPLC 2011
会议名称: 37th International Symposium on High Performance Liquid Phase Separations and Related Techniques
会议日期: 2011-10-8
出版日期: 2011
会议地点: 大连
通讯作者: 许国旺
出版者: 待补充
出版地: 待补充
合作性质: 墙报
部门归属: 1808
主办者: 中国化学会色谱专业委员会
摘要: Lipidomics is a rising field and has been concerned by more and more researchers, due to lipid metabolism is one of the three metabolism of human being, and various influencing human health diseases all have a relationship with lipids, such as cancer, diabetes and heart disease. Liquid chromatography is a powerful tool for the separation and analysis of lipids. Although the separation technique is developed constantly, one dimensional chromatography still has not sufficient power to separate the lipids in comprehensive biological samples adequately, neither a reverse phase chromatography, nor a normal phase chromatography. In our study, we developed an off-line two dimensional chromatography method for separation and analysis of lipids from comprehensive biological samples. A diol normal phase column was employed as the first dimension, and a T3 reverse phase column was used as the second dimension. The retention time of the first dimension was stabilized by suitable equilibrium condition, so the lipid fractions were enriched and much more lipids of liver have been identified by the off-line two dimensional systems than that by only the first dimension.
英文摘要: Lipidomics is a rising field and has been concerned by more and more researchers, due to lipid metabolism is one of the three metabolism of human being, and various influencing human health diseases all have a relationship with lipids, such as cancer, diabetes and heart disease. Liquid chromatography is a powerful tool for the separation and analysis of lipids. Although the separation technique is developed constantly, one dimensional chromatography still has not sufficient power to separate the lipids in comprehensive biological samples adequately, neither a reverse phase chromatography, nor a normal phase chromatography. In our study, we developed an off-line two dimensional chromatography method for separation and analysis of lipids from comprehensive biological samples. A diol normal phase column was employed as the first dimension, and a T3 reverse phase column was used as the second dimension. The retention time of the first dimension was stabilized by suitable equilibrium condition, so the lipid fractions were enriched and much more lipids of liver have been identified by the off-line two dimensional systems than that by only the first dimension.
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/116064
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Zhao SM,Yang Q,Shi XZ,et al. Development of off-line two dimensional liquid chromatography-mass[C]. 见:37th International Symposium on High Performance Liquid Phase Separations and Related Techniques. 大连. 2011-10-8.
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