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学科主题分析化学
Development of off-line two dimensional liquid chromatography-mass
Zhao SM(赵素敏); Yang Q(杨芹); Shi XZ(石先哲); Lu X(路鑫); Xu GW(许国旺)
会议文集Proceeding of HPLC 2011
会议名称37th International Symposium on High Performance Liquid Phase Separations and Related Techniques
会议日期2011-10-8
2011
会议地点大连
页码451-0
出版者待补充
出版地待补充
合作性质墙报
部门归属1808
主办者中国化学会色谱专业委员会
英文摘要Lipidomics is a rising field and has been concerned by more and more researchers, due to lipid metabolism is one of the three metabolism of human being, and various influencing human health diseases all have a relationship with lipids, such as cancer, diabetes and heart disease. Liquid chromatography is a powerful tool for the separation and analysis of lipids. Although the separation technique is developed constantly, one dimensional chromatography still has not sufficient power to separate the lipids in comprehensive biological samples adequately, neither a reverse phase chromatography, nor a normal phase chromatography. In our study, we developed an off-line two dimensional chromatography method for separation and analysis of lipids from comprehensive biological samples. A diol normal phase column was employed as the first dimension, and a T3 reverse phase column was used as the second dimension. The retention time of the first dimension was stabilized by suitable equilibrium condition, so the lipid fractions were enriched and much more lipids of liver have been identified by the off-line two dimensional systems than that by only the first dimension.; Lipidomics is a rising field and has been concerned by more and more researchers, due to lipid metabolism is one of the three metabolism of human being, and various influencing human health diseases all have a relationship with lipids, such as cancer, diabetes and heart disease. Liquid chromatography is a powerful tool for the separation and analysis of lipids. Although the separation technique is developed constantly, one dimensional chromatography still has not sufficient power to separate the lipids in comprehensive biological samples adequately, neither a reverse phase chromatography, nor a normal phase chromatography. In our study, we developed an off-line two dimensional chromatography method for separation and analysis of lipids from comprehensive biological samples. A diol normal phase column was employed as the first dimension, and a T3 reverse phase column was used as the second dimension. The retention time of the first dimension was stabilized by suitable equilibrium condition, so the lipid fractions were enriched and much more lipids of liver have been identified by the off-line two dimensional systems than that by only the first dimension.
文献类型会议论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/116064
专题中国科学院大连化学物理研究所
通讯作者Xu GW(许国旺)
推荐引用方式
GB/T 7714
Zhao SM,Yang Q,Shi XZ,et al. Development of off-line two dimensional liquid chromatography-mass[C]. 待补充:待补充,2011:451-0.
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