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学科主题: 分析化学
题名: Bile acids as Novel Indicator of Hepatocellular Carcinoma: Small-Molecule Markers Screening from Bile Fluid to Serum
作者: Wang WZ(王文昭) ;  YexiongTan ;  YiHong ;  Yin PY(尹沛源) ;  LiangTang ;  Gao P(高鹏) ;  MinWang ;  Huang Q(黄强) ;  Chen J(陈静) ;  Li X(李响) ;  LiweiDong ;  Zhao XJ(赵欣捷) ;  ZhenzhenYao ;  Lu X(路鑫) ;  Xu GW(许国旺) ;  HongyangWang
会议文集: Proceeding of HPLC 2011
会议名称: 37th International Symposium on High Performance Liquid Phase Separations and Related Techniques
会议日期: 2011-10-8
出版日期: 2011
会议地点: 大连
通讯作者: 许国旺
出版者: 待补充
出版地: 待补充
合作性质: 墙报
部门归属: 1808
主办者: 中国化学会色谱专业委员会
摘要: The identification of a sensitive and specific serum marker will facilitate the early diagnosis of hepatocellular carcinoma (HCC) and increase patient survival rates. In this study, bile fluid from 82 patients suffering from hepatic carcinoma (n=40), gall-stone (n=20), cystic polypi (n=15) and hepatic benign lesions (n=7) were analyzed through a high-efficient Ultra Performance Liquid Chromatography (UPLC) mass spectrometry metabolic profiling strategy. The acquired data were subjected to orthogonal signal correction-partial least squares discriminate analysis (OSC-PLSDA) to extract the significant bile fluid components that played a key role in defining the disease state. Subsequently, univariate analysis was utilized to narrow the scope of potential metabolic markers that were HCC specific. Finally, a bile acid that had elevated concentrations in the bile fluid as well as in the sera of HCC patients was screened out. By using this bile acid as a marker, the HCC screening sensitivity increased from 62% (based on alpha-fetoprotein, AFP) to 93%. Conclusion: These findings demonstrated that bile acid would be useful serum indicator for HCC diagnosis.
英文摘要: The identification of a sensitive and specific serum marker will facilitate the early diagnosis of hepatocellular carcinoma (HCC) and increase patient survival rates. In this study, bile fluid from 82 patients suffering from hepatic carcinoma (n=40), gall-stone (n=20), cystic polypi (n=15) and hepatic benign lesions (n=7) were analyzed through a high-efficient Ultra Performance Liquid Chromatography (UPLC) mass spectrometry metabolic profiling strategy. The acquired data were subjected to orthogonal signal correction-partial least squares discriminate analysis (OSC-PLSDA) to extract the significant bile fluid components that played a key role in defining the disease state. Subsequently, univariate analysis was utilized to narrow the scope of potential metabolic markers that were HCC specific. Finally, a bile acid that had elevated concentrations in the bile fluid as well as in the sera of HCC patients was screened out. By using this bile acid as a marker, the HCC screening sensitivity increased from 62% (based on alpha-fetoprotein, AFP) to 93%. Conclusion: These findings demonstrated that bile acid would be useful serum indicator for HCC diagnosis.
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/116070
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Wang WZ,YexiongTan,YiHong,et al. Bile acids as Novel Indicator of Hepatocellular Carcinoma: Small-Molecule Markers Screening from Bile Fluid to Serum[C]. 见:37th International Symposium on High Performance Liquid Phase Separations and Related Techniques. 大连. 2011-10-8.
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