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学科主题分析化学
System Toxicology Research of Tripterygium wilfordii Hook. f. on Female Rat Using LC-MS Based Urinary Metabolomics
Kong HW(孔宏伟); YingYu; Xu ZL(许智良); Zhang FX(张凤霞); Dai WD(戴伟东); Xu GW(许国旺)
会议文集Proceeding of HPLC 2011
会议名称37th International Symposium on High Performance Liquid Phase Separations and Related Techniques
会议日期2011-10-8
2011
会议地点大连
页码488-0
出版者待补充
出版地待补充
合作性质墙报
部门归属1808
主办者中国化学会色谱专业委员会
英文摘要Tripterygium wilfordii Hook. f. has a long history of use in traditional Chinese herbal medicine. It is used for the treatment of arthritis, muscle injury, skin diseases, and other diseases. However, it is thought to be toxic or even fatal if taken to excess. Here, a metabolomics- based toxicology approach was used to elucidate the toxicity in SD female rats induced by tripterygiumon. Overnight 12 h urine samples were collected from rats exposed to three different doses and healthy controls at predose and at the 3rd, 5th, 9th, 14th, 19th and 26th day postdose. Urinary metabolic profiling was analyzed by principal component analysis (PCA) to find the differential metabolites and altered biological pathways which are in response of herbal toxin. The results showed that tripterygiumon caused a dose-dependent and time-dependent toxic and it perturbed metabolic regulatory network to disorder amino acid, purine and choline metabolism pathways. Metabolomics can be a systems approach to provide comprehensive information of drug induced toxicity. With metabolomics, the systemic toxic effects can be detected at an earlier stage compared to the histopathological assessment.; Tripterygium wilfordii Hook. f. has a long history of use in traditional Chinese herbal medicine. It is used for the treatment of arthritis, muscle injury, skin diseases, and other diseases. However, it is thought to be toxic or even fatal if taken to excess. Here, a metabolomics- based toxicology approach was used to elucidate the toxicity in SD female rats induced by tripterygiumon. Overnight 12 h urine samples were collected from rats exposed to three different doses and healthy controls at predose and at the 3rd, 5th, 9th, 14th, 19th and 26th day postdose. Urinary metabolic profiling was analyzed by principal component analysis (PCA) to find the differential metabolites and altered biological pathways which are in response of herbal toxin. The results showed that tripterygiumon caused a dose-dependent and time-dependent toxic and it perturbed metabolic regulatory network to disorder amino acid, purine and choline metabolism pathways. Metabolomics can be a systems approach to provide comprehensive information of drug induced toxicity. With metabolomics, the systemic toxic effects can be detected at an earlier stage compared to the histopathological assessment.
文献类型会议论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/116071
专题中国科学院大连化学物理研究所
通讯作者Xu GW(许国旺)
推荐引用方式
GB/T 7714
Kong HW,YingYu,Xu ZL,et al. System Toxicology Research of Tripterygium wilfordii Hook. f. on Female Rat Using LC-MS Based Urinary Metabolomics[C]. 待补充:待补充,2011:488-0.
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