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学科主题: 分析化学
题名: System Toxicology Research of Tripterygium wilfordii Hook. f. on Female Rat Using LC-MS Based Urinary Metabolomics
作者: Kong HW(孔宏伟) ;  YingYu ;  Xu ZL(许智良) ;  Zhang FX(张凤霞) ;  Dai WD(戴伟东) ;  Xu GW(许国旺)
会议文集: Proceeding of HPLC 2011
会议名称: 37th International Symposium on High Performance Liquid Phase Separations and Related Techniques
会议日期: 2011-10-8
出版日期: 2011
会议地点: 大连
通讯作者: 许国旺
出版者: 待补充
出版地: 待补充
合作性质: 墙报
部门归属: 1808
主办者: 中国化学会色谱专业委员会
摘要: Tripterygium wilfordii Hook. f. has a long history of use in traditional Chinese herbal medicine. It is used for the treatment of arthritis, muscle injury, skin diseases, and other diseases. However, it is thought to be toxic or even fatal if taken to excess. Here, a metabolomics- based toxicology approach was used to elucidate the toxicity in SD female rats induced by tripterygiumon. Overnight 12 h urine samples were collected from rats exposed to three different doses and healthy controls at predose and at the 3rd, 5th, 9th, 14th, 19th and 26th day postdose. Urinary metabolic profiling was analyzed by principal component analysis (PCA) to find the differential metabolites and altered biological pathways which are in response of herbal toxin. The results showed that tripterygiumon caused a dose-dependent and time-dependent toxic and it perturbed metabolic regulatory network to disorder amino acid, purine and choline metabolism pathways. Metabolomics can be a systems approach to provide comprehensive information of drug induced toxicity. With metabolomics, the systemic toxic effects can be detected at an earlier stage compared to the histopathological assessment.
英文摘要: Tripterygium wilfordii Hook. f. has a long history of use in traditional Chinese herbal medicine. It is used for the treatment of arthritis, muscle injury, skin diseases, and other diseases. However, it is thought to be toxic or even fatal if taken to excess. Here, a metabolomics- based toxicology approach was used to elucidate the toxicity in SD female rats induced by tripterygiumon. Overnight 12 h urine samples were collected from rats exposed to three different doses and healthy controls at predose and at the 3rd, 5th, 9th, 14th, 19th and 26th day postdose. Urinary metabolic profiling was analyzed by principal component analysis (PCA) to find the differential metabolites and altered biological pathways which are in response of herbal toxin. The results showed that tripterygiumon caused a dose-dependent and time-dependent toxic and it perturbed metabolic regulatory network to disorder amino acid, purine and choline metabolism pathways. Metabolomics can be a systems approach to provide comprehensive information of drug induced toxicity. With metabolomics, the systemic toxic effects can be detected at an earlier stage compared to the histopathological assessment.
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/116071
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Kong HW,YingYu,Xu ZL,et al. System Toxicology Research of Tripterygium wilfordii Hook. f. on Female Rat Using LC-MS Based Urinary Metabolomics[C]. 见:37th International Symposium on High Performance Liquid Phase Separations and Related Techniques. 大连. 2011-10-8.
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