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学科主题: 分析化学
题名: Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases
作者: Zhou LN(周丽娜) ;  QuancaiWang ;  Yin PY(尹沛源) ;  WenbinXing ;  Wu ZM(吴泽明) ;  Chen SL(陈世礼) ;  Lu X(路鑫) ;  YongZhang ;  Lin XH(林晓惠) ;  Xu GW(许国旺)
会议文集: Proceeding of HPLC 2011
会议名称: 37th International Symposium on High Performance Liquid Phase Separations and Related Techniques
会议日期: 2011-10-8
出版日期: 2011
会议地点: 大连
通讯作者: 许国旺
出版者: 待补充
出版地: 待补充
合作性质: 墙报
部门归属: 1808
主办者: 中国化学会色谱专业委员会
摘要: Patients with chronic liver diseases (CLD) including chronic hepatitis B (CHB) and hepatic cirrhosis (CIR) are major high risk population of hepatocellular carcinoma (HCC). And the differential diagnosis between CLD and HCC is a challenge. This study aims at studying the related metabolic deregulations in HCC and CLD to promote the discovery of the differential metabolites for distinguishing the different liver diseases. Serum metabolic profiling analysis from patients with CLD and HCC was performed using a liquid chromatography-mass spectrometry system. And the acquired huge amount of metabolic information was processed with the random forest – recursive feature elimination (RF-RFE) method to discover important metabolic changes. It was found that there was a declining serum level of tryptophan, medium and short-chain acylcarnitines and an increasing level of cortisol, glycocholic acid (GCA), chenodeoxycholic acid glycine conjugate (GCDCA), C16:1-acylcarnitine in liver diseases. Especially, long-chain acylcarnitines accumulated, whereas free carnitine, medium and short-chain acylcarnitines decreased with the severity of the non-malignant liver diseases, accompanied with corresponding alterations of enzyme activities. However, the general changing extent was smaller in HCC than in CIR, possibly due to special energy-consumption mechanism of tumor cells. These discoveries may help to understand the mechanism of HCC occurrence and progression on the metabolic level and provide information for the identification of early and differential metabolic markers for HCC.
英文摘要: Patients with chronic liver diseases (CLD) including chronic hepatitis B (CHB) and hepatic cirrhosis (CIR) are major high risk population of hepatocellular carcinoma (HCC). And the differential diagnosis between CLD and HCC is a challenge. This study aims at studying the related metabolic deregulations in HCC and CLD to promote the discovery of the differential metabolites for distinguishing the different liver diseases. Serum metabolic profiling analysis from patients with CLD and HCC was performed using a liquid chromatography-mass spectrometry system. And the acquired huge amount of metabolic information was processed with the random forest – recursive feature elimination (RF-RFE) method to discover important metabolic changes. It was found that there was a declining serum level of tryptophan, medium and short-chain acylcarnitines and an increasing level of cortisol, glycocholic acid (GCA), chenodeoxycholic acid glycine conjugate (GCDCA), C16:1-acylcarnitine in liver diseases. Especially, long-chain acylcarnitines accumulated, whereas free carnitine, medium and short-chain acylcarnitines decreased with the severity of the non-malignant liver diseases, accompanied with corresponding alterations of enzyme activities. However, the general changing extent was smaller in HCC than in CIR, possibly due to special energy-consumption mechanism of tumor cells. These discoveries may help to understand the mechanism of HCC occurrence and progression on the metabolic level and provide information for the identification of early and differential metabolic markers for HCC.
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/116072
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Zhou LN,QuancaiWang,Yin PY,et al. Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases[C]. 见:37th International Symposium on High Performance Liquid Phase Separations and Related Techniques. 大连. 2011-10-8.
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