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学科主题分析化学
Study of oral cancer based on integrating plasma, urine and saliva metabolic profiles by Gas Chromatography-Mass Spectrometry and Liquid Chromatography-Mass Spectrometry
He HB(和红兵); Shi XZ(石先哲); Chen J(陈静); Gao P(高鹏); Xu GW(许国旺)
会议文集Proceeding of HPLC 2011
会议名称37th International Symposium on High Performance Liquid Phase Separations and Related Techniques
会议日期2011-10-8
2011
会议地点大连
页码490-0
出版者待补充
出版地待补充
合作性质墙报
部门归属1808
主办者中国化学会色谱专业委员会
英文摘要Oral cancer is the eighth most common cancer worldwide with an overall 5-year survival rate of less than 50%. Precise differentiation of benign and malignant tumors plays key roles in proper and timely selection of the therapeutic treatment. This study will pay more attention to screening valuable markers by comparing a more complete metabolite profiles in the relevant biofluids (plasma, urine and saliva) from the control, benign and malignant oral tumor patients. In the current study, plasma, urine and saliva metabolic profiles for three groups consisting of malignant oral tumor patients, benign oral tumor patients and healthy controls were performed using ultra performance liquid chromatography coupled with quadrupole/time-of-flight mass spectrometry and gas chromatography coupled with mass spectrometry, respectively. After peak alignment, 964 metabolic features had been detected from three metabolic profiles including 409 from plasma, 448 from urine and 107 from saliva, respectively. Utilizing multivariate chemometric analysis, excellent discriminations were obtained among the three groups based on their plasma, urine and saliva metabolic profiles, respectively. Over twenty discriminatory metabolites from plasma, urine and saliva were identified. The identified metabolites were discussed in the context of their involved pathways and biological activities. These results indicated malignant oral tumor patients show altered energy metabolism, a disorder lipolysis and a distorted Krebs cycle compared with benign oral tumor patients and healthy controls. In addition, plasma, urine and saliva metabolism are intimately correlated in human body. Our results implied that a more complete picture of the metabolic pathways in oral cancer can be achieved by integrating plasma, urine and saliva profiles of the same patients and controls simultaneously. It will helpful for further underlying mechanisms of oral cancer.; Oral cancer is the eighth most common cancer worldwide with an overall 5-year survival rate of less than 50%. Precise differentiation of benign and malignant tumors plays key roles in proper and timely selection of the therapeutic treatment. This study will pay more attention to screening valuable markers by comparing a more complete metabolite profiles in the relevant biofluids (plasma, urine and saliva) from the control, benign and malignant oral tumor patients. In the current study, plasma, urine and saliva metabolic profiles for three groups consisting of malignant oral tumor patients, benign oral tumor patients and healthy controls were performed using ultra performance liquid chromatography coupled with quadrupole/time-of-flight mass spectrometry and gas chromatography coupled with mass spectrometry, respectively. After peak alignment, 964 metabolic features had been detected from three metabolic profiles including 409 from plasma, 448 from urine and 107 from saliva, respectively. Utilizing multivariate chemometric analysis, excellent discriminations were obtained among the three groups based on their plasma, urine and saliva metabolic profiles, respectively. Over twenty discriminatory metabolites from plasma, urine and saliva were identified. The identified metabolites were discussed in the context of their involved pathways and biological activities. These results indicated malignant oral tumor patients show altered energy metabolism, a disorder lipolysis and a distorted Krebs cycle compared with benign oral tumor patients and healthy controls. In addition, plasma, urine and saliva metabolism are intimately correlated in human body. Our results implied that a more complete picture of the metabolic pathways in oral cancer can be achieved by integrating plasma, urine and saliva profiles of the same patients and controls simultaneously. It will helpful for further underlying mechanisms of oral cancer.
文献类型会议论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/116073
专题中国科学院大连化学物理研究所
通讯作者Xu GW(许国旺)
推荐引用方式
GB/T 7714
He HB,Shi XZ,Chen J,et al. Study of oral cancer based on integrating plasma, urine and saliva metabolic profiles by Gas Chromatography-Mass Spectrometry and Liquid Chromatography-Mass Spectrometry[C]. 待补充:待补充,2011:490-0.
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