DICP OpenIR
Subject Area生物化学
Chitosan Oligosaccharides Protect Human Monocytes U937 from LPS-induced Inflammatory Damage through Blockade p38 MAPK Phosphorylation and Increasing O-GlcNAcylation of Proteins
Li Y(李昱); Peng Q(彭强); Xu QS(许青松); Du YG(杜昱光); YuguangDu
Source PublicationAsian Communications of Glycobiology and Glycotechnology
Conference NameThe 3rd Asian Communications of Glycobiology and Glycotechnology
Conference Date2011-10-27
2011
Conference Place上海
Alternative Title壳寡糖通过阻断p38 MAPK磷酸化增加蛋白O-GlcNAc修饰保护人单核细胞U937遭受LPS诱导的炎症损伤
Pages69-0
Publisher待补充
Publication Place待补充
Cooperation Status墙报
Department1805
Funding Organization中国科学院上海有机化学所
AbstractTo investigate the effects of Chitosan oligosaccharides(COS) with different degree of polymerization(DP) on LPS-induced inflammation, U937 human monocytes were cultured with DP2-8(COS-A) and DP7-15(COS-B) respectively, which were prepared by our group. The results showed that both kinds of COS demonstrated obviously anti-inflammatory effects against LPS-induced over-expression of TNF-α and IL-8. Signal transduction studies indicated COS-A and COS-B efficiently down-regulated LPS-induced the phosphorylation of p38 MAPK. In several documented instances, phosphorylation and O-GlcNAc modification are reciprocal, occurring at the same or adjacent hydroxyl moieties. In this study, we also find COS-A and COS -B could significantly increase O-GlcNAc modification of proteins in LPS-induced U937 monocytes. Finally, we postulate that COS-A and COS-B may have anti-inflammatory effects via suppression of the expression levels of TNF-α and IL-8, regulated by p38 MAPK pathways and O-GlcNAcylation of proteins.; To investigate the effects of Chitosan oligosaccharides(COS) with different degree of polymerization(DP) on LPS-induced inflammation, U937 human monocytes were cultured with DP2-8(COS-A) and DP7-15(COS-B) respectively, which were prepared by our group. The results showed that both kinds of COS demonstrated obviously anti-inflammatory effects against LPS-induced over-expression of TNF-α and IL-8. Signal transduction studies indicated COS-A and COS-B efficiently down-regulated LPS-induced the phosphorylation of p38 MAPK. In several documented instances, phosphorylation and O-GlcNAc modification are reciprocal, occurring at the same or adjacent hydroxyl moieties. In this study, we also find COS-A and COS -B could significantly increase O-GlcNAc modification of proteins in LPS-induced U937 monocytes. Finally, we postulate that COS-A and COS-B may have anti-inflammatory effects via suppression of the expression levels of TNF-α and IL-8, regulated by p38 MAPK pathways and O-GlcNAcylation of proteins.
Document Type会议论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/116085
Collection中国科学院大连化学物理研究所
Corresponding AuthorYuguangDu
Recommended Citation
GB/T 7714
Li Y,Peng Q,Xu QS,et al. Chitosan Oligosaccharides Protect Human Monocytes U937 from LPS-induced Inflammatory Damage through Blockade p38 MAPK Phosphorylation and Increasing O-GlcNAcylation of Proteins[C]. 待补充:待补充,2011:69-0.
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