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学科主题: 生物化学
题名: Chitosan Oligosaccharides Protect Human Monocytes U937 from LPS-induced Inflammatory Damage through Blockade p38 MAPK Phosphorylation and Increasing O-GlcNAcylation of Proteins
作者: Li Y(李昱) ;  Peng Q(彭强) ;  Xu QS(许青松) ;  Du YG(杜昱光)
会议文集: Asian Communications of Glycobiology and Glycotechnology
会议名称: The 3rd Asian Communications of Glycobiology and Glycotechnology
会议日期: 2011-10-27
出版日期: 2011
会议地点: 上海
其他题名: 壳寡糖通过阻断p38 MAPK磷酸化增加蛋白O-GlcNAc修饰保护人单核细胞U937遭受LPS诱导的炎症损伤
通讯作者: YuguangDu
出版者: 待补充
出版地: 待补充
合作性质: 墙报
部门归属: 1805
主办者: 中国科学院上海有机化学所
摘要: To investigate the effects of Chitosan oligosaccharides(COS) with different degree of polymerization(DP) on LPS-induced inflammation, U937 human monocytes were cultured with DP2-8(COS-A) and DP7-15(COS-B) respectively, which were prepared by our group. The results showed that both kinds of COS demonstrated obviously anti-inflammatory effects against LPS-induced over-expression of TNF-α and IL-8. Signal transduction studies indicated COS-A and COS-B efficiently down-regulated LPS-induced the phosphorylation of p38 MAPK. In several documented instances, phosphorylation and O-GlcNAc modification are reciprocal, occurring at the same or adjacent hydroxyl moieties. In this study, we also find COS-A and COS -B could significantly increase O-GlcNAc modification of proteins in LPS-induced U937 monocytes. Finally, we postulate that COS-A and COS-B may have anti-inflammatory effects via suppression of the expression levels of TNF-α and IL-8, regulated by p38 MAPK pathways and O-GlcNAcylation of proteins.
英文摘要: To investigate the effects of Chitosan oligosaccharides(COS) with different degree of polymerization(DP) on LPS-induced inflammation, U937 human monocytes were cultured with DP2-8(COS-A) and DP7-15(COS-B) respectively, which were prepared by our group. The results showed that both kinds of COS demonstrated obviously anti-inflammatory effects against LPS-induced over-expression of TNF-α and IL-8. Signal transduction studies indicated COS-A and COS-B efficiently down-regulated LPS-induced the phosphorylation of p38 MAPK. In several documented instances, phosphorylation and O-GlcNAc modification are reciprocal, occurring at the same or adjacent hydroxyl moieties. In this study, we also find COS-A and COS -B could significantly increase O-GlcNAc modification of proteins in LPS-induced U937 monocytes. Finally, we postulate that COS-A and COS-B may have anti-inflammatory effects via suppression of the expression levels of TNF-α and IL-8, regulated by p38 MAPK pathways and O-GlcNAcylation of proteins.
内容类型: 会议论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/116085
Appears in Collections:中国科学院大连化学物理研究所_会议论文

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Recommended Citation:
Li Y,Peng Q,Xu QS,et al. Chitosan Oligosaccharides Protect Human Monocytes U937 from LPS-induced Inflammatory Damage through Blockade p38 MAPK Phosphorylation and Increasing O-GlcNAcylation of Proteins[C]. 见:The 3rd Asian Communications of Glycobiology and Glycotechnology. 上海. 2011-10-27.
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