中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
学科主题: 物理化学
题名: Development and evaluation of new imidazolium-based zwitterionic stationary phases for hydrophilic interaction chromatography
作者: Qiao, Lizhen1;  Dou, Abo1;  Shi, Xianzhe1;  Li, Hua1;  Shan, Yuanhong1;  Lu, Xin1;  Xu, Guowang1
通讯作者: 石先哲 ;  许国旺
关键词: Imidazolium ;  Zwitterionic stationary phase ;  Hydrophilic interaction chromatography ;  Core-shell ;  Ionic liquid
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2013-04-19
DOI: 10.1016/j.chroma.2013.02.066
卷: 1286, 页:137-145
收录类别: SCI ;  ISTP
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 1,1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Hydrophilic interaction liquid chromatography (HILIC) has been widely used for separating polar compounds as a complement mode to reversed-phase liquid chromatography. The development of new stationary phases for HILIC is significant to improve the coverage of various polar and hydrophilic compounds. The present study described the preparation and application of novel imidazolium-based zwitterionic stationary phases. 1-Vinyl-3-(butyl-4-sulfonate) imidazolium was synthesized from 1-vinylimidazole and 1,4-butane sultone, then bonded to the surface of 3-mercaptopropyl modified silica particles (core-shell silica and totally porous silica) by "thiol-ene" click chemistry to obtain the resulting zwitterionic stationary phase with a positively charged imidazole ring and a negatively charged sulfonate group. The zwitterionic stationary phases exhibited good selectivity and favorable retention for a wide range of polar solutes (nucleosides, nucleic acid bases, benzoic organic acids, uric acid and its methyl derivatives, water-soluble vitamins) as compared to a bare silica column. The column efficiency could reach up to 100,000 theoretical plates/m with cytosine as the test solute. The retention changes of various types of test solutes were investigated under different chromatographic conditions including water content, pH, buffer salt concentration in mobile phase and column temperature. The results indicated that the retention of solutes on the stationary phase was the outcome of a mixed-mode retention mechanism (i.e. a combination of adsorptive and partitioning interactions). In conclusion, the new imidazolium-based zwitterionic stationary phases have shown excellent chromatographic behavior for a variety of polar solutes under HILIC mode, and have a great potential as a new type of stationary phases for HILIC. (c) 2013 Elsevier B.V. All rights reserved.
关键词[WOS]: INTERACTION LIQUID-CHROMATOGRAPHY ;  CONFINED IONIC LIQUID ;  RETENTION BEHAVIOR ;  GAS-CHROMATOGRAPHY ;  REVERSED-PHASE ;  MOBILE-PHASE ;  URIC-ACID ;  MASS-SPECTROMETRY ;  POLAR COMPOUNDS ;  SEPARATION
语种: 英语
WOS记录号: WOS:000317156100016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/117595
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2013mhTTULJ3zv.PDF(1118KB)----开放获取--View Download

作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

Recommended Citation:
Qiao, Lizhen,Dou, Abo,Shi, Xianzhe,et al. Development and evaluation of new imidazolium-based zwitterionic stationary phases for hydrophilic interaction chromatography[J]. JOURNAL OF CHROMATOGRAPHY A,2013,1286:137-145.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Qiao, Lizhen]'s Articles
 [Dou, Abo]'s Articles
 [Shi, Xianzhe]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Qiao, Lizhen]‘s Articles
 [Dou, Abo]‘s Articles
 [Shi, Xianzhe]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
文件名: 2013mhTTULJ3zv.PDF
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace