中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
学科主题: 物理化学
题名: Investigation of peptoid chiral stationary phases varied in absolute configuration
作者: Wu, Haibo1;  Li, Kuiyong1;  Yu, Hui1;  Ke, Yanxiong1;  Liang, Xinmiao1, 2
通讯作者: 柯燕雄 ;  梁鑫淼
关键词: Peptoid ;  Oligopeptoid ;  Diastereoisomeric selectors ;  Chiral stationary phase
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2013-03-15
DOI: 10.1016/j.chroma.2013.01.073
卷: 1281, 页:155-159
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1803
产权排名: 2,5
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Based on chiral N-(1-phenylethyl) glycines, a series of peptoid chiral stationary phases (CSPs) terminated with achiral alkyl group (diisopropyl, t-butyl or n-butyl) and varied in absolute configuration of selector were investigated with nine axially chiral analytes. It is very interesting to observe that selectors with heterogeneous configuration form, such as S-R-R, S-R-S, S-S-R, generally performed better than S-S-S selectors. Moreover, longer S-R-S-R-S selector did not outperform the S-R-S one obviously, with several separations declined. In addition to the result that the elution order of most enantiomers depends on the asymmetric center adjacent to the terminus of selector, we presume that the moieties around this chiral center are the most important absorbing sites for chiral discrimination; the terminal group and other chiral blocks in selector may assist enantiorecognition by constructing appropriate conformation. Various terminal alkyl groups also resulted in a few differences in enantioselectivity. (C) 2013 Published by Elsevier B.V.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  VARYING PEPTIDE LENGTH ;  CAPILLARY-ELECTROPHORESIS ;  SIDE-CHAINS ;  RECOGNITION ;  SELECTORS ;  ENANTIOMERS ;  SEPARATION ;  HPLC ;  ENANTIOSEPARATIONS
语种: 英语
WOS记录号: WOS:000315552700021
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/117620
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2013HGWjn0m0DB.PDF(501KB)----开放获取--View 联系获取全文

作者单位: 1.E China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Wu, Haibo,Li, Kuiyong,Yu, Hui,et al. Investigation of peptoid chiral stationary phases varied in absolute configuration[J]. JOURNAL OF CHROMATOGRAPHY A,2013,1281:155-159.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Wu, Haibo]'s Articles
 [Li, Kuiyong]'s Articles
 [Yu, Hui]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Wu, Haibo]‘s Articles
 [Li, Kuiyong]‘s Articles
 [Yu, Hui]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
文件名: 2013HGWjn0m0DB.PDF
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace