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学科主题: 物理化学
题名: The effect of electrostatic microencapsulation process on biological properties of tumour cells
作者: Li, Nan1, 2;  Xu, Xiao-Xi1, 2;  Sun, Guang-Wei1;  Guo, Xin1;  Liu, Yang1;  Wang, Shu-Jun1, 3;  Zhang, Ying1;  Yu, Wei-Ting1;  Wang, Wei1;  Ma, Xiao-Jun1
通讯作者: 孙广炜
关键词: alginate ;  apoptosis ;  endoplasmic reticulum ;  microencapsulation
刊名: JOURNAL OF MICROENCAPSULATION
发表日期: 2013
DOI: 10.3109/02652048.2012.758181
卷: 30, 期:6, 页:530-537
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1802
产权排名: 1,1
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Applied ;  Engineering, Chemical ;  Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ;  Engineering ;  Pharmacology & Pharmacy
英文摘要: Microencapsulation is one of the promising strategies to develop a three-dimensional in vivo tumour-mimic model in cancer research. Although previous studies have shown that tumour cells grow well during the microencapsulated culture, it is still not clear whether the electrostatic encapsulation process has an important effect on cellular characteristics. In this study, we investigated cellular response against non-physiological stress factors existing in the electrostatic microencapsulation process, such as the high-voltage electrostatic field, suspension and nutrition-free status. Our results showed that these non-physiological stress factors did not significantly induce cellular apoptosis, and did not affect cellular adhesion and viability. Furthermore, no change was found about invasion and drug resistance of the tumour cells. The normal endoplasmic reticulum function might play a role in maintaining biological properties during the electrostatic microencapsulation process.
关键词[WOS]: ENDOPLASMIC-RETICULUM STRESS ;  SPHEROID MODEL ;  FLOW-CYTOMETRY ;  STEM-CELLS ;  IN-VITRO ;  VIABILITY ;  ADHESION ;  THERAPY ;  CANCER ;  DIFFERENTIATION
语种: 英语
WOS记录号: WOS:000322255900003
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/117624
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian 116024, Peoples R China

Recommended Citation:
Li, Nan,Xu, Xiao-Xi,Sun, Guang-Wei,et al. The effect of electrostatic microencapsulation process on biological properties of tumour cells[J]. JOURNAL OF MICROENCAPSULATION,2013,30(6):530-537.
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