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学科主题: 物理化学
题名: Metabolic Characterization of Hepatocellular Carcinoma Using Nontargeted Tissue Metabolomics
作者: Huang, Qiang1;  Tan, Yexiong2;  Yin, Peiyuan1;  Ye, Guozhu1;  Gao, Peng1;  Lu, Xin1;  Wang, Hongyang2;  Xu, Guowang1
通讯作者: 许国旺
刊名: CANCER RESEARCH
发表日期: 2013-08-15
DOI: 10.1158/0008-5472.CAN-13-0308
卷: 73, 期:16, 页:4992-5002
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 1,1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Oncology
研究领域[WOS]: Oncology
英文摘要: Hepatocellular carcinoma has a poor prognosis due to its rapid development and early metastasis. In this report, we characterized the metabolic features of hepatocellular carcinoma using a nontargeted metabolic profiling strategy based on liquid chromatography-mass spectrometry. Fifty pairs of liver cancer samples and matched normal tissues were collected from patients having hepatocellular carcinoma, including tumor tissues, adjacent noncancerous tissues, and distal noncancerous tissues, and 105 metabolites were filtered and identified from the tissue metabolome. The principal metabolic alternations in HCC tumors included elevated glycolysis, gluconeogenesis, and beta-oxidation with reduced tricarboxylic acid cycle and Delta-12 desaturase. Furthermore, increased levels of glutathione and other antioxidative molecules, together with decreased levels of inflammatory-related polyunsaturated fatty acids and phospholipase A2, were observed. Differential metabolite levels in tissues were tested in 298 serum specimens from patients with chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Betaine and propionylcarnitine were confirmed to confer good diagnostic potential to distinguish hepatocellular carcinoma from chronic hepatitis and cirrhosis. External validation of cirrhosis and hepatocellular carcinoma serum specimens further showed that this combination biomarker is useful for diagnosis of hepatocellular carcinoma with a supplementary role to alpha-fetoprotein. (C) 2013 AACR.
关键词[WOS]: MASS-SPECTROMETRY ;  CANCER-CELLS ;  COLORECTAL-CANCER ;  PRIMARY LIVER ;  METABONOMICS ;  EXPRESSION ;  BIOMARKERS ;  GLUTAMINE ;  HALLMARKS ;  STRESS
语种: 英语
WOS记录号: WOS:000323161800005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/117637
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Second Mil Med Univ, Int Cooperat Lab Signal Transduct, Eastern Hepatobiliary Surg Inst, Shanghai, Peoples R China

Recommended Citation:
Huang, Qiang,Tan, Yexiong,Yin, Peiyuan,et al. Metabolic Characterization of Hepatocellular Carcinoma Using Nontargeted Tissue Metabolomics[J]. CANCER RESEARCH,2013,73(16):4992-5002.
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