DICP OpenIR
Subject Area物理化学
Metabolic Characterization of Hepatocellular Carcinoma Using Nontargeted Tissue Metabolomics
Huang, Qiang1; Tan, Yexiong2; Yin, Peiyuan1; Ye, Guozhu1; Gao, Peng1; Lu, Xin1; Wang, Hongyang2; Xu, Guowang1; Xu GW(许国旺)
Source PublicationCANCER RESEARCH
2013-08-15
DOI10.1158/0008-5472.CAN-13-0308
Volume73Issue:16Pages:4992-5002
Indexed BySCI
SubtypeArticle
Department18
Funding Project1808
Contribution Rank1,1
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectOncology
WOS Research AreaOncology
WOS KeywordMASS-SPECTROMETRY ; CANCER-CELLS ; COLORECTAL-CANCER ; PRIMARY LIVER ; METABONOMICS ; EXPRESSION ; BIOMARKERS ; GLUTAMINE ; HALLMARKS ; STRESS
AbstractHepatocellular carcinoma has a poor prognosis due to its rapid development and early metastasis. In this report, we characterized the metabolic features of hepatocellular carcinoma using a nontargeted metabolic profiling strategy based on liquid chromatography-mass spectrometry. Fifty pairs of liver cancer samples and matched normal tissues were collected from patients having hepatocellular carcinoma, including tumor tissues, adjacent noncancerous tissues, and distal noncancerous tissues, and 105 metabolites were filtered and identified from the tissue metabolome. The principal metabolic alternations in HCC tumors included elevated glycolysis, gluconeogenesis, and beta-oxidation with reduced tricarboxylic acid cycle and Delta-12 desaturase. Furthermore, increased levels of glutathione and other antioxidative molecules, together with decreased levels of inflammatory-related polyunsaturated fatty acids and phospholipase A2, were observed. Differential metabolite levels in tissues were tested in 298 serum specimens from patients with chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Betaine and propionylcarnitine were confirmed to confer good diagnostic potential to distinguish hepatocellular carcinoma from chronic hepatitis and cirrhosis. External validation of cirrhosis and hepatocellular carcinoma serum specimens further showed that this combination biomarker is useful for diagnosis of hepatocellular carcinoma with a supplementary role to alpha-fetoprotein. (C) 2013 AACR.
Language英语
WOS IDWOS:000323161800005
Citation statistics
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/117637
Collection中国科学院大连化学物理研究所
Corresponding AuthorXu GW(许国旺)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Second Mil Med Univ, Int Cooperat Lab Signal Transduct, Eastern Hepatobiliary Surg Inst, Shanghai, Peoples R China
Recommended Citation
GB/T 7714
Huang, Qiang,Tan, Yexiong,Yin, Peiyuan,et al. Metabolic Characterization of Hepatocellular Carcinoma Using Nontargeted Tissue Metabolomics[J]. CANCER RESEARCH,2013,73(16):4992-5002.
APA Huang, Qiang.,Tan, Yexiong.,Yin, Peiyuan.,Ye, Guozhu.,Gao, Peng.,...&许国旺.(2013).Metabolic Characterization of Hepatocellular Carcinoma Using Nontargeted Tissue Metabolomics.CANCER RESEARCH,73(16),4992-5002.
MLA Huang, Qiang,et al."Metabolic Characterization of Hepatocellular Carcinoma Using Nontargeted Tissue Metabolomics".CANCER RESEARCH 73.16(2013):4992-5002.
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