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学科主题: 物理化学
题名: Study of stereomeric peptoid chiral stationary phases containing different chiral side chains
作者: Wu, Haibo1;  Song, Guangjun1;  Wang, Dongqiang1;  Yu, Hui1;  Ke, Yanxiong1;  Liang, Xinmiao1, 2
通讯作者: 柯燕雄 ;  梁鑫淼
关键词: Peptoid ;  Enantiomeric separation ;  Stereomeric selectors ;  Chiral stationary phase
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2013-07-12
DOI: 10.1016/j.chroma.2013.05.035
卷: 1298, 页:152-156
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1803
产权排名: 2,6
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: In this study, we investigated six stereomeric peptoid chiral stationary phases (CSPs) successively combining N'-phenyl-proline amide, alpha-phenylethyl amine, 2-amino cyclohexyl phenylcarbamate and another a-phenylethyl amine under normal phase mode. CSPs 1-4 with R-S-(R,R)-S, R-S-(S,S)-S, R-R-(R,R)-R and R-R-(S,S)-R configuration exhibited much different enantiorecognition abilities. Overall, CSPs 1 and 2 performed better for the 55 analytes tested. CSP 5 with mixed selectors combined partial selectivities of CSPs 1 and 2. CSP 6 as enantiomeric counterpart of CSP 2 exhibited similar enantioseparation ability and reversal elution orders for analytes resolved. For several biaryl type analytes, CSP 6 even outperformed commercial Chiralpak AD-H and Chiralcel OD-H. Excellent resolution of 3,3'-diphenyl-2,2'-bi-1-naphthalol (VANOL) on CSP 6 illustrated its potential application in preparative enantioseparation. Eluting orders of enantiomers on stereomeric CSPs also provided us further insight into enantiorecognition of some analytes. (C) 2013 Elsevier B.V. All rights reserved.
关键词[WOS]: ENANTIOMERIC SEPARATIONS ;  ABSOLUTE-CONFIGURATION ;  IMPROVEMENT ;  RESOLUTION ;  SELECTOR ;  ACIDS ;  HPLC
语种: 英语
WOS记录号: WOS:000321174700019
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/117661
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.E China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Sch Pharm, Shanghai 200237, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Wu, Haibo,Song, Guangjun,Wang, Dongqiang,et al. Study of stereomeric peptoid chiral stationary phases containing different chiral side chains[J]. JOURNAL OF CHROMATOGRAPHY A,2013,1298:152-156.
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