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学科主题: 物理化学
题名: Differences between the metabolic profiles of decompensated and compensated cirrhosis patients with Hepatitis B virus infections under high-performance liquid chromatography-mass spectrometry
作者: Chen, Yu1, 2;  Xu, Zhiliang3;  Kong, Hongwei3;  Chen, Nan2;  Chen, Jing3;  Zhou, Lina3;  Wang, Feiling4;  Dong, Yuejiao2;  Zheng, Shufa2;  Chen, Zhenjing2;  Xu, Guowang3;  Li, Lanjuan1
通讯作者: 孔宏伟 ;  LanjuanLi
关键词: Metabolomics ;  Hepatitis B ;  HPLC-MS ;  Compensated liver cirrhosis ;  Decompensated liver cirrhosis ;  Child-turcotte-pugh scoring
刊名: METABOLOMICS
发表日期: 2012-10-01
DOI: 10.1007/s11306-011-0379-z
卷: 8, 期:5, 页:845-853
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 3,2
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
英文摘要: To improve the grading and staging of liver cirrhosis among patients with HBV infection noninvasively, a high-performance liquid chromatography with mass spectrometry metabolomics method was used to investigate the potential metabolic biomarkers in the serum of patients with different degrees of hepatic cirrhosis. The results demonstrate that lysophosphatidyl choline (LPC) from positive electrospray ionization (ESI) mode, and fatty acids and bile acids from negative ESI mode play important roles in distinguishing decompensated from compensated cirrhosis. A total of 21 differential metabolites were found from the two groups of patients. LPCs, fatty acids, and taurocholic acid (TCA) 3-sulfate decreased in patients with decompensated cirrhosis, whereas other bile acids increased significantly. The levels of TCA 3-sulfate, LPC 16:0, and LPC 18:0 were significantly correlated with the stages of the decompensated cirrhosis, and they may serve as potential biomarkers for the stage assessment of liver cirrhosis in patients with HBV infections.
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ;  LIVER-CIRRHOSIS ;  BILE-ACIDS ;  BIOMARKERS ;  SERUM ;  METABONOMICS ;  DISEASE ;  BIOPSY ;  RAT
语种: 英语
WOS记录号: WOS:000309681300009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/117726
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Zhejiang Univ, Sch Med, State Key Lab Diag & Treatment Infect Dis, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China
2.Zhejiang Univ, Coll Med, Affiliated Hosp 1, Ctr Clin Lab, Hangzhou 310003, Zhejiang, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
4.Wenzhou Med Coll, Wenzhou, Peoples R China

Recommended Citation:
Chen, Yu,Xu, Zhiliang,Kong, Hongwei,et al. Differences between the metabolic profiles of decompensated and compensated cirrhosis patients with Hepatitis B virus infections under high-performance liquid chromatography-mass spectrometry[J]. METABOLOMICS,2012,8(5):845-853.
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