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学科主题: 物理化学
题名: Recent Advancement of Chemical Derivatization and Its Applications to High Sensitive Analysis of Peptide in Mass Spectrometry
作者: Qiao Xiao-Qiang1, 2, 3;  Wang Rui1, 2;  Zhang Li-Hua3;  Yang Geng-Liang1, 2;  Zhang Yu-Kui3
通讯作者: 乔晓强
关键词: Chemical derivatization ;  High sensitive detection ;  Mass spectrometry ;  Peptide ;  Review
刊名: CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
发表日期: 2012-07-01
DOI: 10.1016/S1872-2040(11)60560-4
卷: 40, 期:7, 页:1123-1129
收录类别: SCI
文章类型: Review
部门归属: 18
项目归属: 1810
产权排名: 2,1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Shotgun based strategy is a widely used method in proteome research. However, due to the high complexity and wide dynamic range, the detection sensitivity of peptides, especially for those with low abundance and low ionization efficiency, still can hardly meet the requirements. Chemical derivatization has been proved to be one of the most promising methods. Herein, the recent progress in the development of derivatization reagents targeting for the peptides as well as those with post-translational modifications, and its applications in high sensitive analysis in mass spectrometry are reviewed. Furthermore, the future research directions and the potential application in proteome research are discussed.
关键词[WOS]: ASSISTED-LASER-DESORPTION/IONIZATION ;  MALDI-QIT-TOFMSN ;  ELECTROSPRAY-IONIZATION ;  STRUCTURAL DETERMINATION ;  SIGNAL ENHANCEMENT ;  TRYPTIC PEPTIDES ;  MS/MS ANALYSIS ;  AMINO-GROUPS ;  MATRIX ;  OLIGOSACCHARIDES
语种: 英语
WOS记录号: WOS:000308253300005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/117804
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Hebei Univ, Key Lab Pharmaceut Qual Control Hebei Prov, Baoding 071002, Peoples R China
2.Hebei Univ, Coll Pharmaceut Sci, Baoding 071002, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

Recommended Citation:
Qiao Xiao-Qiang,Wang Rui,Zhang Li-Hua,et al. Recent Advancement of Chemical Derivatization and Its Applications to High Sensitive Analysis of Peptide in Mass Spectrometry[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2012,40(7):1123-1129.
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