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学科主题: 物理化学
题名: Investigation of Family 18 Chitinases and Inhibitors by Computer-Aided Approaches
作者: Chu, Huiying1;  Wang, Jinan2;  Shen, Hujun1;  Yang, Yongliang1, 3;  Zhu, Weiliang2;  Li, Guohui1
通讯作者: YangYongliang ;  ZhuWeiliang ;  李国辉
关键词: Chitinases ;  chitinase inhibitors ;  computer-aided approach
刊名: CURRENT DRUG TARGETS
发表日期: 2012-04-01
卷: 13, 期:4, 页:502-511
收录类别: SCI
文章类型: Review
部门归属: 11
项目归属: 1106
产权排名: 1,1
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要: Chitinases belong to family 18 glycosyl hydrolases that can hydrolyze chitin by cleaving beta-1,4-glycosidic bond, and are at key points in the life cycles of organism. The inhibitors of chitinases not only have chemotherapeutic potential against fungi, insects, but also hold anti-inflammatory efficacy against asthma and allergic disease in human. This review summarizes the structural characters of chitinases, the proposed catalytic mechanism, furthermore, also gives descriptions of currently existing inhibitors. In addition, computational studies of the interaction modes of chitinases with different inhibitors and substrates, as well as the inhibitor design of chitinases, are summarized so as to obtain an overall understanding for chitinases.
关键词[WOS]: ACIDIC MAMMALIAN CHITINASE ;  SUBSTRATE-ASSISTED CATALYSIS ;  PRODUCT CYCLOPENTAPEPTIDE INHIBITORS ;  MOLECULAR-DYNAMICS SIMULATIONS ;  X-RAY-STRUCTURE ;  SERRATIA-MARCESCENS ;  COMPUTATIONAL ANALYSIS ;  SACCHAROMYCES-CEREVISIAE ;  CHITINOLYTIC ENZYMES ;  BACTERIAL CHITINASES
语种: 英语
WOS记录号: WOS:000301928000006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/117855
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Mol Modeling & Design, State Key Lab Mol React Dynam, Beijing 100864, Peoples R China
2.Chinese Acad Sci, Drug Discovery & Design Ctr, Shanghai Inst Mat Med, Beijing 100864, Peoples R China
3.Dalian Univ Technol, Ctr Mol Med, Dept Biol Engn, Dalian 116023, Peoples R China

Recommended Citation:
Chu, Huiying,Wang, Jinan,Shen, Hujun,et al. Investigation of Family 18 Chitinases and Inhibitors by Computer-Aided Approaches[J]. CURRENT DRUG TARGETS,2012,13(4):502-511.
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