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学科主题物理化学
A pyrene-imidazolium derivative that selectively Recognizes G-Quadruplex DNA
Kim, Ha Na1; Lee, Eun-Hae2,3; Xu, Zhaochao1,4; Kim, Hee-Eun2,3; Lee, Hee-Seung5; Lee, Joon-Hwa2,3; Yoon, Juyoung1,6; WenjunWu; DavidRSpring
关键词G-quadruplex Nmr Fluorescent Sensor Imidazolium Pyrene Excimer Emission
刊名BIOMATERIALS
2012-03-01
ISSN0142-9612
DOI10.1016/j.biomaterials.2011.11.073
33期:7页:2282-2288
收录类别SCI
文章类型Article
部门归属18
项目归属18T2
产权排名3,3
WOS标题词Science & Technology ; Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]COLORIMETRIC CHEMOSENSORS ; FLUORESCENT-PROBE ; RECENT PROGRESS ; POTASSIUM-ION ; BINDING ; TRANSITION ; PARALLEL ; FLUORIDE ; RECEPTOR ; BINDERS
英文摘要G-quadruplexes, formed of four stranded guanine bases stabilized by monovalent cations, serve important role in cancer cell growth and control gene expression in telomere. Since there are various types of quadruplex structures, rapid and simple screening methods with high selectivity, sensitivity and nontoxicity are required for understanding about the biological roles of quadruplex DNA as well as in designing therapeutics. Herein, we report a pyrene-imidazolium derivative, JY-1, which can with high selectivity recognize G-quadruplex using fluorescence and NMR spectroscopy. This is the first example based on the imidazolium derivative, which can detect the G-quadruplex directly to utilize the excimer/monomer emission change in pyrene fluorophore. The selectivity of strong binding to a specific sequence can allow for quadruplex sensing and the detection method presented here is very simple, using fluorescence and NMR study. Also, the groove binding characteristic of JY-1 to the G-quadruplex has a relatively low nonspecific toxicity and the structure-specific differences in fluorescent character between DNA duplex and G-quadruplex may offer more discovery and application in biological study. (C) 2011 Elsevier Ltd. All rights reserved.
语种英语
WOS记录号WOS:000300473900035
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/117860
专题中国科学院大连化学物理研究所
通讯作者WenjunWu; DavidRSpring
作者单位1.Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea
2.Gyeongsang Natl Univ, Dept Chem, Jinju 660701, Gyeongnam, South Korea
3.Gyeongsang Natl Univ, RINS, Jinju 660701, Gyeongnam, South Korea
4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
5.Korea Adv Inst Sci & Technol, Dept Chem, Mol Level Interface Res Ctr, Taejon 305701, South Korea
6.Ewha Womans Univ, Dept Bioinspired Sci, Seoul 120750, South Korea
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GB/T 7714
Kim, Ha Na,Lee, Eun-Hae,Xu, Zhaochao,et al. A pyrene-imidazolium derivative that selectively Recognizes G-Quadruplex DNA[J]. BIOMATERIALS,2012,33(7):2282-2288.
APA Kim, Ha Na.,Lee, Eun-Hae.,Xu, Zhaochao.,Kim, Hee-Eun.,Lee, Hee-Seung.,...&DavidRSpring.(2012).A pyrene-imidazolium derivative that selectively Recognizes G-Quadruplex DNA.BIOMATERIALS,33(7),2282-2288.
MLA Kim, Ha Na,et al."A pyrene-imidazolium derivative that selectively Recognizes G-Quadruplex DNA".BIOMATERIALS 33.7(2012):2282-2288.
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