DICP OpenIR
Subject Area物理化学
A pyrene-imidazolium derivative that selectively Recognizes G-Quadruplex DNA
Kim, Ha Na1; Lee, Eun-Hae2,3; Xu, Zhaochao1,4; Kim, Hee-Eun2,3; Lee, Hee-Seung5; Lee, Joon-Hwa2,3; Yoon, Juyoung1,6; WenjunWu; DavidRSpring
KeywordG-quadruplex Nmr Fluorescent Sensor Imidazolium Pyrene Excimer Emission
Source PublicationBIOMATERIALS
2012-03-01
ISSN0142-9612
DOI10.1016/j.biomaterials.2011.11.073
Volume33Issue:7Pages:2282-2288
Indexed BySCI
SubtypeArticle
Department18
Funding Project18T2
Contribution Rank3,3
WOS HeadingsScience & Technology ; Technology
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS Research AreaEngineering ; Materials Science
WOS KeywordCOLORIMETRIC CHEMOSENSORS ; FLUORESCENT-PROBE ; RECENT PROGRESS ; POTASSIUM-ION ; BINDING ; TRANSITION ; PARALLEL ; FLUORIDE ; RECEPTOR ; BINDERS
AbstractG-quadruplexes, formed of four stranded guanine bases stabilized by monovalent cations, serve important role in cancer cell growth and control gene expression in telomere. Since there are various types of quadruplex structures, rapid and simple screening methods with high selectivity, sensitivity and nontoxicity are required for understanding about the biological roles of quadruplex DNA as well as in designing therapeutics. Herein, we report a pyrene-imidazolium derivative, JY-1, which can with high selectivity recognize G-quadruplex using fluorescence and NMR spectroscopy. This is the first example based on the imidazolium derivative, which can detect the G-quadruplex directly to utilize the excimer/monomer emission change in pyrene fluorophore. The selectivity of strong binding to a specific sequence can allow for quadruplex sensing and the detection method presented here is very simple, using fluorescence and NMR study. Also, the groove binding characteristic of JY-1 to the G-quadruplex has a relatively low nonspecific toxicity and the structure-specific differences in fluorescent character between DNA duplex and G-quadruplex may offer more discovery and application in biological study. (C) 2011 Elsevier Ltd. All rights reserved.
Language英语
WOS IDWOS:000300473900035
Citation statistics
Cited Times:37[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/117860
Collection中国科学院大连化学物理研究所
Corresponding AuthorWenjunWu; DavidRSpring
Affiliation1.Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea
2.Gyeongsang Natl Univ, Dept Chem, Jinju 660701, Gyeongnam, South Korea
3.Gyeongsang Natl Univ, RINS, Jinju 660701, Gyeongnam, South Korea
4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
5.Korea Adv Inst Sci & Technol, Dept Chem, Mol Level Interface Res Ctr, Taejon 305701, South Korea
6.Ewha Womans Univ, Dept Bioinspired Sci, Seoul 120750, South Korea
Recommended Citation
GB/T 7714
Kim, Ha Na,Lee, Eun-Hae,Xu, Zhaochao,et al. A pyrene-imidazolium derivative that selectively Recognizes G-Quadruplex DNA[J]. BIOMATERIALS,2012,33(7):2282-2288.
APA Kim, Ha Na.,Lee, Eun-Hae.,Xu, Zhaochao.,Kim, Hee-Eun.,Lee, Hee-Seung.,...&DavidRSpring.(2012).A pyrene-imidazolium derivative that selectively Recognizes G-Quadruplex DNA.BIOMATERIALS,33(7),2282-2288.
MLA Kim, Ha Na,et al."A pyrene-imidazolium derivative that selectively Recognizes G-Quadruplex DNA".BIOMATERIALS 33.7(2012):2282-2288.
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