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学科主题: 物理化学
题名: A pyrene-imidazolium derivative that selectively Recognizes G-Quadruplex DNA
作者: Kim, Ha Na1;  Lee, Eun-Hae2, 3;  Xu, Zhaochao1, 4;  Kim, Hee-Eun2, 3;  Lee, Hee-Seung5;  Lee, Joon-Hwa2, 3;  Yoon, Juyoung1, 6
通讯作者: WenjunWu ;  DavidRSpring
关键词: G-quadruplex ;  NMR ;  Fluorescent sensor ;  Imidazolium ;  Pyrene ;  Excimer emission
刊名: BIOMATERIALS
发表日期: 2012-03-01
DOI: 10.1016/j.biomaterials.2011.11.073
卷: 33, 期:7, 页:2282-2288
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 18T2
产权排名: 3,3
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Engineering, Biomedical ;  Materials Science, Biomaterials
研究领域[WOS]: Engineering ;  Materials Science
英文摘要: G-quadruplexes, formed of four stranded guanine bases stabilized by monovalent cations, serve important role in cancer cell growth and control gene expression in telomere. Since there are various types of quadruplex structures, rapid and simple screening methods with high selectivity, sensitivity and nontoxicity are required for understanding about the biological roles of quadruplex DNA as well as in designing therapeutics. Herein, we report a pyrene-imidazolium derivative, JY-1, which can with high selectivity recognize G-quadruplex using fluorescence and NMR spectroscopy. This is the first example based on the imidazolium derivative, which can detect the G-quadruplex directly to utilize the excimer/monomer emission change in pyrene fluorophore. The selectivity of strong binding to a specific sequence can allow for quadruplex sensing and the detection method presented here is very simple, using fluorescence and NMR study. Also, the groove binding characteristic of JY-1 to the G-quadruplex has a relatively low nonspecific toxicity and the structure-specific differences in fluorescent character between DNA duplex and G-quadruplex may offer more discovery and application in biological study. (C) 2011 Elsevier Ltd. All rights reserved.
关键词[WOS]: COLORIMETRIC CHEMOSENSORS ;  FLUORESCENT-PROBE ;  RECENT PROGRESS ;  POTASSIUM-ION ;  BINDING ;  TRANSITION ;  PARALLEL ;  FLUORIDE ;  RECEPTOR ;  BINDERS
语种: 英语
WOS记录号: WOS:000300473900035
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/117860
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea
2.Gyeongsang Natl Univ, Dept Chem, Jinju 660701, Gyeongnam, South Korea
3.Gyeongsang Natl Univ, RINS, Jinju 660701, Gyeongnam, South Korea
4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
5.Korea Adv Inst Sci & Technol, Dept Chem, Mol Level Interface Res Ctr, Taejon 305701, South Korea
6.Ewha Womans Univ, Dept Bioinspired Sci, Seoul 120750, South Korea

Recommended Citation:
Kim, Ha Na,Lee, Eun-Hae,Xu, Zhaochao,et al. A pyrene-imidazolium derivative that selectively Recognizes G-Quadruplex DNA[J]. BIOMATERIALS,2012,33(7):2282-2288.
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