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学科主题: 物理化学
题名: Probing the role of mesenchymal stem cells in salivary gland cancer on biomimetic microdevices
作者: Ma, Huipeng1;  Zhang, Min1;  Qin, Jianhua1
通讯作者: 秦建华
刊名: INTEGRATIVE BIOLOGY
发表日期: 2012
DOI: 10.1039/c2ib20026k
卷: 4, 期:5, 页:522-530
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1807
产权排名: 1,1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
英文摘要: Mesenchymal stem cells (MSCs) are the progenitors of stromal cells, which have been found to interact with cancer cells and represent an important target for cancer therapies. Salivary gland cancer is an aggressive malignant epithelial tumor and can easily disseminate to distant sites in vivo. In this work, we probed the role of MSCs in salivary gland cancer in an in vivo like tumor microenvironment by using a series of functional microfluidic devices for 2D and 3D assays. The results demonstrated that MSCs could be recruited by salivary gland cancer cells (ACC-M) and this effect was potentially mediated by TGF-beta secreted by cancer cells. In addition, MSCs exhibited the ability to squeeze into ACC-M spheroids by dispersing the cell-cell connection and reducing the expression of E-cadherin in cancer cells. In particular, MSCs exhibited the ability to enhance the invasion of salivary cancer under a chemokine CXCL12 gradient, indicating the involvement of a CXCL12-CXCR4 pathway and the tumor-promoting properties of MSCs in cancer progression. This study recreated an in vivo-like tumor microenvironment by constructing a series of functional microdevices and explored the role of MSCs in ACC invasion for the first time. It provides a unique platform to open up new options to target stromal cells for cancer therapy and also analyzed the potential risk of using MSCs as drug delivery carriers for therapeutic purposes in carcinoma treatment.
关键词[WOS]: ADENOID CYSTIC CARCINOMA ;  MARROW STROMAL CELLS ;  TUMOR-CELLS ;  FIBROBLASTS ;  CXCR4 ;  METASTASIS ;  GROWTH ;  LUNG ;  THERAPIES ;  MELANOMA
语种: 英语
WOS记录号: WOS:000303321100007
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/117875
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Beijing 100864, Peoples R China

Recommended Citation:
Ma, Huipeng,Zhang, Min,Qin, Jianhua. Probing the role of mesenchymal stem cells in salivary gland cancer on biomimetic microdevices[J]. INTEGRATIVE BIOLOGY,2012,4(5):522-530.
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