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学科主题: 物理化学
题名: Plasma metabonomics study of rheumatoid arthritis and its Chinese medicine subtypes by using liquid chromatography and gas chromatography coupled with mass spectrometry
作者: Gu, Yan2, 3;  Lu, Cheng1;  Zha, Qinglin1;  Kong, Hongwei2;  Lu, Xin2;  Lu, Aiping1;  Xu, Guowang2
通讯作者: 许国旺 ;  AipingLu
刊名: MOLECULAR BIOSYSTEMS
发表日期: 2012
DOI: 10.1039/c2mb25022e
卷: 8, 期:5, 页:1535-1543
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 1,1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
英文摘要: Rheumatoid arthritis (RA) is the most severe type of chronic inflammatory disease and has always been a research hotspot in different fields. In this study, a non-targeted metabonomics approach was carried out to profile metabolic characteristics of RA and its Chinese medicine subtypes by using liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS). Plasma samples of 57 RA patients and 23 healthy controls were collected. On the basis of the traditional Chinese medicine (TCM), RA patients were classified into two main patterns, the cold pattern and the heat pattern. By using univariate and multivariate data analysis, we found that the RA patients presented diverse dysfunctions in inositol phosphate metabolism, lipid metabolism, amino acid metabolism, glucose metabolism, ascorbate metabolism, glyoxylate and dicarboxylate metabolism. The metabolic phenotypes were different between the RA cold pattern and the RA heat pattern. Compared with the RA cold pattern, the RA heat pattern showed elevated plasma concentrations of glycochenodeoxycholate, proline, saturated and mono-unsaturated phosphatidylcholine (PC) but decreased levels of urea, free fatty acid (FFA) and polyunsaturated PC. Our data show that metabonomics is a valuable tool in disease and TCM subtype research.
关键词[WOS]: SYSTEMIC-LUPUS-ERYTHEMATOSUS ;  OXIDATIVE STRESS ;  HPLC-MS ;  PROTEIN ;  DEGRADATION ;  COLLAGEN ;  VALIDATION ;  STRATEGY ;  MARKER ;  BONE
语种: 英语
WOS记录号: WOS:000302368600019
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/117900
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China
2.Chinese Acad Sci, Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut Anal, Shenyang 110016, Peoples R China

Recommended Citation:
Gu, Yan,Lu, Cheng,Zha, Qinglin,et al. Plasma metabonomics study of rheumatoid arthritis and its Chinese medicine subtypes by using liquid chromatography and gas chromatography coupled with mass spectrometry[J]. MOLECULAR BIOSYSTEMS,2012,8(5):1535-1543.
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