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学科主题物理化学
Promoted activity of Cr(Salen) in a nanoreactor for kinetic resolution of terminal epoxides
Bai, Shiyang1,2; Li, Bo1; Peng, Juan1,2; Zhang, Xiaoming1,2; Yang, Qihua1; Li, Can1; Yang QH(杨启华); Li C(李灿)
刊名CHEMICAL SCIENCE
2012
DOI10.1039/c2sc20653f
3期:9页:2864-2867
收录类别SCI
文章类型Article
部门归属5
项目归属506;503
产权排名1, 1
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]RING-OPENING REACTIONS ; SALEN COMPLEXES ; ASYMMETRIC CATALYSIS ; MESOPOROUS SILICA ; METAL-COMPLEXES ; CR-III(SALEN) ; IMPREGNATION ; CAGE
英文摘要Cr(Salen) catalyzed kinetic resolution of terminal epoxides via asymmetric ring opening (ARO) with TMSN3 is an important approach for the synthesis of enantiopure 1,2-amino alcohols, however, the high catalyst usage amount (1-2 mol%) impedes its practical applications. An efficient solid nanoreactor was constructed by encapsulation of Cr(Salen) and pyridine in the nanocages of mesoporous silica. This solid nanoreactor exhibits high activity (TOF: 1325 h(-1)) and high enantioselectivity (91% ee) for the kinetic resolution of 1,2-epoxyhexane via ARO with TMSN3 at a catalyst concentration as low as 0.002 mol%, whereas the homogeneous counterpart affords almost no conversion of epoxide under similar reaction conditions. The high activity of the solid nanoreactor is mainly attributed to the greatly intensified cooperative activation in the nanocages as evidenced by the sharply increased TOF in parallel with Cr(Salen) concentration in each nanocage. The increased nucleophilicity of Cr(Salen) after coordination to pyridine could also promote the catalytic activity. The solid nanoreactor can be easily separated and recycled. We demonstrated the possibility for designing an efficient solid nanoreactor for asymmetric catalysis by taking the advantages of the cooperative activation.
语种英语
WOS记录号WOS:000306931300029
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/117933
专题中国科学院大连化学物理研究所
通讯作者Yang QH(杨启华); Li C(李灿)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
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GB/T 7714
Bai, Shiyang,Li, Bo,Peng, Juan,et al. Promoted activity of Cr(Salen) in a nanoreactor for kinetic resolution of terminal epoxides[J]. CHEMICAL SCIENCE,2012,3(9):2864-2867.
APA Bai, Shiyang.,Li, Bo.,Peng, Juan.,Zhang, Xiaoming.,Yang, Qihua.,...&李灿.(2012).Promoted activity of Cr(Salen) in a nanoreactor for kinetic resolution of terminal epoxides.CHEMICAL SCIENCE,3(9),2864-2867.
MLA Bai, Shiyang,et al."Promoted activity of Cr(Salen) in a nanoreactor for kinetic resolution of terminal epoxides".CHEMICAL SCIENCE 3.9(2012):2864-2867.
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