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学科主题: 物理化学
题名: Isobaric cross-sequence labeling of peptides by using site-selective N-terminus dimethylation
作者: Qin, Hongqiang1;  Wang, Fangjun1;  Zhang, Yi1;  Hu, Zhengyan1;  Song, Chunxia1;  Wu, Ren'an1;  Ye, Mingliang1;  Zou, Hanfa1
通讯作者: 邹汉法
刊名: CHEMICAL COMMUNICATIONS
发表日期: 2012
DOI: 10.1039/c2cc31705b
卷: 48, 期:50, 页:6265-6267
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1809
产权排名: 1,1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: Highly site-selective dimethyl labeling of N-terminus of peptides has been obtained by adjusting the acidic strength of the reaction solution. And this selective labeling strategy combined with the use of different isotope formaldehyde reagents has been successfully used in the proteome quantification by using the isobaric peptide cross-sequence labeling method, which would play increasingly important roles in the clinical diagnosis, especially in the discovery of biomarkers for diseases.
关键词[WOS]: ORGANOCATALYTIC REDUCTIVE AMINATION ;  QUANTITATIVE PROTEOMICS ;  CLEAVAGE SITES ;  LIVING CELLS ;  PROTEIN
语种: 英语
WOS记录号: WOS:000304486800018
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/117941
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, CAS Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Qin, Hongqiang,Wang, Fangjun,Zhang, Yi,et al. Isobaric cross-sequence labeling of peptides by using site-selective N-terminus dimethylation[J]. CHEMICAL COMMUNICATIONS,2012,48(50):6265-6267.
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