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学科主题: 物理化学
题名: Flexible Generation of Gradient Electrospinning Nanofibers Using a Microfluidic Assisted Approach
作者: Zhang, Xu1, 2;  Gao, Xinghua1, 2;  Jiang, Lei1;  Qin, Jianhua1
通讯作者: 秦建华
刊名: LANGMUIR
发表日期: 2012-06-03
DOI: 10.1021/la300821r
卷: 28, 期:26, 页:10026-10032
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1807
产权排名: 1,1
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Chemistry, Multidisciplinary ;  Chemistry, Physical ;  Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ;  Materials Science
英文摘要: The nanofiber surface modified with physical or chemical gradients is very useful in a wide range of areas including tissue engineering, regenerative medicine, drug screening, and biomaterial chemistry. In this work, we presented a novel and straightforward microfluidic assisted approach to produce electrospinning nanofibers containing gradients in different compositions, nanoparticles and biomolecule concentrations. The series of gradient nanofibers were mainly produced by using a two inlet microfluidic device in combination with an electrospinning nozzle on a 3-D controllable platform, which exhibited different functions and properties. The controlled nanofibers with incorporated biomolecule gradient were used for guiding the spatial differentiation in mesenchymal stem cells (MSCs). This established approach is very simple, and flexible to operate, which might find enormous potential for biology and tissue engineering applications.
关键词[WOS]: MESENCHYMAL STEM-CELLS ;  BONE DEFECTS ;  SCAFFOLDS ;  FIBERS ;  TISSUE ;  PROMOTION
语种: 英语
WOS记录号: WOS:000305869500016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/117953
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

Recommended Citation:
Zhang, Xu,Gao, Xinghua,Jiang, Lei,et al. Flexible Generation of Gradient Electrospinning Nanofibers Using a Microfluidic Assisted Approach[J]. LANGMUIR,2012,28(26):10026-10032.
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