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学科主题: 物理化学
题名: A microfluidic-based device for study of transendothelial invasion of tumor aggregates in realtime
作者: Zhang, Qian1;  Liu, Tingjiao1;  Qin, Jianhua2
通讯作者: TingjiaoLiu ;  秦建华
刊名: LAB ON A CHIP
发表日期: 2012
DOI: 10.1039/c2lc00030j
卷: 12, 期:16, 页:2837-2842
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1807
产权排名: 2,3
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Multidisciplinary ;  Nanoscience & Nanotechnology
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry ;  Science & Technology - Other Topics
英文摘要: Circulating tumor aggregates exhibit a high metastatic potential and could potentially serve as an important target for cancer therapies. In this study, we developed a microfluidic model that reconstitutes and is representative of the principal components of biological blood vessels, including vessel cavity, endothelium, and perivascular matrix containing chemokines. Using this model, the transendothelial invasion of tumor aggregates can be observed and recorded in realtime. In this study we analyzed the extravasation process of salivary gland adenoid cystic carcinoma (ACC) cell aggregates. ACC aggregates transmigrated across the endothelium under the stimulation of chemokine CXCL12. The endothelial integrity was irreversibly damaged at the site of transendothelial invasion. The transendothelial invasion of ACC aggregates was inhibited by AMD3100, but the adhesion of ACC aggregates to the endothelium was not affected by the CXCR4 antagonist. This model allows for detailed study of the attachment and transendothelial invasion of tumor aggregates; thus, it would be a useful tool for analysis of the underlying mechanisms of metastasis and for testing novel anti-metastasis agents.
关键词[WOS]: ADENOID CYSTIC CARCINOMA ;  CANCER METASTASIS ;  IN-VITRO ;  CHEMOKINE RECEPTORS ;  CELLS ;  MIGRATION ;  CXCR4 ;  CHEMOTHERAPY ;  ENDOTHELIUM ;  ADHESION
语种: 英语
WOS记录号: WOS:000306523800012
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/117998
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Med Univ, Coll Stomatol, Sect Oral Pathol, Dalian, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Beijing 100864, Peoples R China

Recommended Citation:
Zhang, Qian,Liu, Tingjiao,Qin, Jianhua. A microfluidic-based device for study of transendothelial invasion of tumor aggregates in realtime[J]. LAB ON A CHIP,2012,12(16):2837-2842.
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