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学科主题物理化学
A microfluidic-based device for study of transendothelial invasion of tumor aggregates in realtime
Zhang, Qian1; Liu, Tingjiao1; Qin, Jianhua2; TingjiaoLiu; Qin JH(秦建华)
刊名LAB ON A CHIP
2012
DOI10.1039/c2lc00030j
12期:16页:2837-2842
收录类别SCI
文章类型Article
部门归属18
项目归属1807
产权排名2,3
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Science & Technology - Other Topics
关键词[WOS]ADENOID CYSTIC CARCINOMA ; CANCER METASTASIS ; IN-VITRO ; CHEMOKINE RECEPTORS ; CELLS ; MIGRATION ; CXCR4 ; CHEMOTHERAPY ; ENDOTHELIUM ; ADHESION
英文摘要Circulating tumor aggregates exhibit a high metastatic potential and could potentially serve as an important target for cancer therapies. In this study, we developed a microfluidic model that reconstitutes and is representative of the principal components of biological blood vessels, including vessel cavity, endothelium, and perivascular matrix containing chemokines. Using this model, the transendothelial invasion of tumor aggregates can be observed and recorded in realtime. In this study we analyzed the extravasation process of salivary gland adenoid cystic carcinoma (ACC) cell aggregates. ACC aggregates transmigrated across the endothelium under the stimulation of chemokine CXCL12. The endothelial integrity was irreversibly damaged at the site of transendothelial invasion. The transendothelial invasion of ACC aggregates was inhibited by AMD3100, but the adhesion of ACC aggregates to the endothelium was not affected by the CXCR4 antagonist. This model allows for detailed study of the attachment and transendothelial invasion of tumor aggregates; thus, it would be a useful tool for analysis of the underlying mechanisms of metastasis and for testing novel anti-metastasis agents.
语种英语
WOS记录号WOS:000306523800012
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/117998
专题中国科学院大连化学物理研究所
通讯作者TingjiaoLiu; Qin JH(秦建华)
作者单位1.Dalian Med Univ, Coll Stomatol, Sect Oral Pathol, Dalian, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Beijing 100864, Peoples R China
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Zhang, Qian,Liu, Tingjiao,Qin, Jianhua,et al. A microfluidic-based device for study of transendothelial invasion of tumor aggregates in realtime[J]. LAB ON A CHIP,2012,12(16):2837-2842.
APA Zhang, Qian,Liu, Tingjiao,Qin, Jianhua,TingjiaoLiu,&秦建华.(2012).A microfluidic-based device for study of transendothelial invasion of tumor aggregates in realtime.LAB ON A CHIP,12(16),2837-2842.
MLA Zhang, Qian,et al."A microfluidic-based device for study of transendothelial invasion of tumor aggregates in realtime".LAB ON A CHIP 12.16(2012):2837-2842.
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