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学科主题物理化学
Potential roles of N-glycosylation in cell adhesion
Gu, Jianguo1; Isaji, Tomoya1; Xu, Qingsong1,2; Kariya, Yoshinobu1,3; Gu, Wei1; Fukuda, Tomohiko1; Du, Yuguang2; JianguoGu
关键词Bisected N-glycan Cell Adhesion E-cadherin N-glycosylation Integrin
刊名GLYCOCONJUGATE JOURNAL
2012-12-01
DOI10.1007/s10719-012-9386-1
29期:8-9页:599-607
收录类别SCI
文章类型Article
部门归属18
项目归属1805
产权排名2,3
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]EPITHELIAL-MESENCHYMAL TRANSITIONS ; ASPARAGINE-LINKED OLIGOSACCHARIDES ; EPIDERMAL-GROWTH-FACTOR ; BETA-PROPELLER DOMAIN ; ACETYLGLUCOSAMINYLTRANSFERASE-III ; E-CADHERIN ; BISECTING GLCNAC ; INTEGRIN ALPHA-V-BETA-3 ; ABERRANT GLYCOSYLATION ; EXTRACELLULAR SEGMENT
英文摘要The functional units of cell adhesion are typically multiprotein complexes made up of three general classes of proteins; the adhesion receptors, the cell-extracellular matrix (ECM) proteins, and the cytoplasmic plaque/peripheral membrane proteins. The cell adhesion receptors are usually transmembrane glycoproteins (for example E-cadherin and integrin) that mediate binding at the extracellular surface and determine the specificity of cell-cell and cell-ECM recognition. E-cadherin-mediated cell-cell adhesion can be both temporally and spatially regulated during development, and represents a key step in the acquisition of the invasive phenotype for many tumors. On the other hand, integrin-mediated cell-ECM interactions play important roles in cytoskeleton organization and in the transduction of intracellular signals to regulate various processes such as proliferation, differentiation and cell migration. ECM proteins are typically large glycoproteins, including the collagens, fibronectins, laminins, and proteoglycans that assemble into fibrils or other complex macromolecular arrays. The most of these adhesive proteins are glycosylated. Here, we focus mainly on the modification of N-glycans of integrins and laminin-332, and a mutual regulation between cell adhesion and bisected N-glycan expression, to address the important roles of N-glycans in cell adhesion.
语种英语
WOS记录号WOS:000309868800005
引用统计
被引频次:68[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/118047
专题中国科学院大连化学物理研究所
通讯作者JianguoGu
作者单位1.Tohoku Pharmaceut Univ, Div Regulatory Glycobiol, Aoba Ku, Sendai, Miyagi 9818558, Japan
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
3.Fukushima Med Univ, Sch Med, Dept Biochem, Fukushima 9601295, Japan
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Gu, Jianguo,Isaji, Tomoya,Xu, Qingsong,et al. Potential roles of N-glycosylation in cell adhesion[J]. GLYCOCONJUGATE JOURNAL,2012,29(8-9):599-607.
APA Gu, Jianguo.,Isaji, Tomoya.,Xu, Qingsong.,Kariya, Yoshinobu.,Gu, Wei.,...&JianguoGu.(2012).Potential roles of N-glycosylation in cell adhesion.GLYCOCONJUGATE JOURNAL,29(8-9),599-607.
MLA Gu, Jianguo,et al."Potential roles of N-glycosylation in cell adhesion".GLYCOCONJUGATE JOURNAL 29.8-9(2012):599-607.
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