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学科主题: 物理化学
题名: Potential roles of N-glycosylation in cell adhesion
作者: Gu, Jianguo1;  Isaji, Tomoya1;  Xu, Qingsong1, 2;  Kariya, Yoshinobu1, 3;  Gu, Wei1;  Fukuda, Tomohiko1;  Du, Yuguang2
通讯作者: JianguoGu
关键词: Bisected N-glycan ;  Cell adhesion ;  E-cadherin ;  N-glycosylation ;  Integrin
刊名: GLYCOCONJUGATE JOURNAL
发表日期: 2012-12-01
DOI: 10.1007/s10719-012-9386-1
卷: 29, 期:8-9, 页:599-607
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1805
产权排名: 2,3
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
英文摘要: The functional units of cell adhesion are typically multiprotein complexes made up of three general classes of proteins; the adhesion receptors, the cell-extracellular matrix (ECM) proteins, and the cytoplasmic plaque/peripheral membrane proteins. The cell adhesion receptors are usually transmembrane glycoproteins (for example E-cadherin and integrin) that mediate binding at the extracellular surface and determine the specificity of cell-cell and cell-ECM recognition. E-cadherin-mediated cell-cell adhesion can be both temporally and spatially regulated during development, and represents a key step in the acquisition of the invasive phenotype for many tumors. On the other hand, integrin-mediated cell-ECM interactions play important roles in cytoskeleton organization and in the transduction of intracellular signals to regulate various processes such as proliferation, differentiation and cell migration. ECM proteins are typically large glycoproteins, including the collagens, fibronectins, laminins, and proteoglycans that assemble into fibrils or other complex macromolecular arrays. The most of these adhesive proteins are glycosylated. Here, we focus mainly on the modification of N-glycans of integrins and laminin-332, and a mutual regulation between cell adhesion and bisected N-glycan expression, to address the important roles of N-glycans in cell adhesion.
关键词[WOS]: EPITHELIAL-MESENCHYMAL TRANSITIONS ;  ASPARAGINE-LINKED OLIGOSACCHARIDES ;  EPIDERMAL-GROWTH-FACTOR ;  BETA-PROPELLER DOMAIN ;  ACETYLGLUCOSAMINYLTRANSFERASE-III ;  E-CADHERIN ;  BISECTING GLCNAC ;  INTEGRIN ALPHA-V-BETA-3 ;  ABERRANT GLYCOSYLATION ;  EXTRACELLULAR SEGMENT
语种: 英语
WOS记录号: WOS:000309868800005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/118047
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Tohoku Pharmaceut Univ, Div Regulatory Glycobiol, Aoba Ku, Sendai, Miyagi 9818558, Japan
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
3.Fukushima Med Univ, Sch Med, Dept Biochem, Fukushima 9601295, Japan

Recommended Citation:
Gu, Jianguo,Isaji, Tomoya,Xu, Qingsong,et al. Potential roles of N-glycosylation in cell adhesion[J]. GLYCOCONJUGATE JOURNAL,2012,29(8-9):599-607.
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