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学科主题: 物理化学
题名: Inhibition of angiogenesis by chitooligosaccharides with specific degrees of acetylation and polymerization
作者: Wu, Haige1, 3;  Aam, Berit B.2;  Wang, Wenxia1;  Norberg, Anne Line2;  Sorlie, Morten2;  Eijsink, Vincent G. H.2;  Du, Yuguang1
通讯作者: 杜昱光
关键词: Chitooligosaccharides (CHOS) ;  Anti-angiogenesis ;  Chitin ;  Chitosan ;  Chitinase ;  Chitosanase
刊名: CARBOHYDRATE POLYMERS
发表日期: 2012-06-20
DOI: 10.1016/j.carbpol.2012.03.037
卷: 89, 期:2, 页:511-518
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1805
产权排名: 1,1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Applied ;  Chemistry, Organic ;  Polymer Science
研究领域[WOS]: Chemistry ;  Polymer Science
英文摘要: Chitooligosaccharides (CHOS) inhibit angiogenesis and may be used in the treatment of cancer tumors. We have studied the effect of the fraction of acetylation (F-A) and the degree of polymerization (DP) on CHOS anti-angiogenic activity. We tested enzymatically produced CHOS-mixtures with F(A)0.15, F(A)0.3 and F(A)0.6, and DP <= 12 in initial experiments with chorioallantoic membranes. All of the samples reduced the formation of new blood vessels, CHOS with F(A)0.3 giving the best effect. Single-DP fractions from the F(A)0.3 sample purified by size-exclusion chromatography (DP3-DP12) were then tested for inhibition of migration of human endothelial cells, which is an important element of the angiogenesis process. All of the fractions inhibited migration, meaning that, within the DP area tested in this study, F-A is more important than DP for the effect. Generally, the results reveal that DP3-DP12 CHOS have considerable potential as anti-angiogenic compounds. (C) 2012 Elsevier Ltd. All rights reserved.
关键词[WOS]: DEACETYLATED CHITINS CHITOSANS ;  STREPTOMYCES-COELICOLOR A3(2) ;  FIELD NMR-SPECTROSCOPY ;  SERRATIA-MARCESCENS ;  IN-VITRO ;  CELLS ;  DEGRADATION ;  MECHANISM ;  OLIGOSACCHARIDES ;  PROCESSIVITY
语种: 英语
WOS记录号: WOS:000304632900029
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/118140
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Norwegian Univ Life Sci, Dept Chem Biotechnol & Food Sci, N-1432 As, Norway
3.Dalian Univ Technol, Bioengn Coll, Dalian 116622, Peoples R China

Recommended Citation:
Wu, Haige,Aam, Berit B.,Wang, Wenxia,et al. Inhibition of angiogenesis by chitooligosaccharides with specific degrees of acetylation and polymerization[J]. CARBOHYDRATE POLYMERS,2012,89(2):511-518.
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