DICP OpenIR
Subject Area物理化学
Inhibition of angiogenesis by chitooligosaccharides with specific degrees of acetylation and polymerization
Wu, Haige1,3; Aam, Berit B.2; Wang, Wenxia1; Norberg, Anne Line2; Sorlie, Morten2; Eijsink, Vincent G. H.2; Du, Yuguang1; Du YG(杜昱光)
KeywordChitooligosaccharides (Chos) Anti-angiogenesis Chitin Chitosan Chitinase Chitosanase
Source PublicationCARBOHYDRATE POLYMERS
2012-06-20
ISSN2270-2278
DOI10.1016/j.carbpol.2012.03.037
Volume89Issue:2Pages:511-518
Indexed BySCI
SubtypeArticle
Department18
Funding Project1805
Contribution Rank1,1
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS Research AreaChemistry ; Polymer Science
WOS KeywordDEACETYLATED CHITINS CHITOSANS ; STREPTOMYCES-COELICOLOR A3(2) ; FIELD NMR-SPECTROSCOPY ; SERRATIA-MARCESCENS ; IN-VITRO ; CELLS ; DEGRADATION ; MECHANISM ; OLIGOSACCHARIDES ; PROCESSIVITY
AbstractChitooligosaccharides (CHOS) inhibit angiogenesis and may be used in the treatment of cancer tumors. We have studied the effect of the fraction of acetylation (F-A) and the degree of polymerization (DP) on CHOS anti-angiogenic activity. We tested enzymatically produced CHOS-mixtures with F(A)0.15, F(A)0.3 and F(A)0.6, and DP <= 12 in initial experiments with chorioallantoic membranes. All of the samples reduced the formation of new blood vessels, CHOS with F(A)0.3 giving the best effect. Single-DP fractions from the F(A)0.3 sample purified by size-exclusion chromatography (DP3-DP12) were then tested for inhibition of migration of human endothelial cells, which is an important element of the angiogenesis process. All of the fractions inhibited migration, meaning that, within the DP area tested in this study, F-A is more important than DP for the effect. Generally, the results reveal that DP3-DP12 CHOS have considerable potential as anti-angiogenic compounds. (C) 2012 Elsevier Ltd. All rights reserved.
Language英语
WOS IDWOS:000304632900029
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/118140
Collection中国科学院大连化学物理研究所
Corresponding AuthorDu YG(杜昱光)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Norwegian Univ Life Sci, Dept Chem Biotechnol & Food Sci, N-1432 As, Norway
3.Dalian Univ Technol, Bioengn Coll, Dalian 116622, Peoples R China
Recommended Citation
GB/T 7714
Wu, Haige,Aam, Berit B.,Wang, Wenxia,et al. Inhibition of angiogenesis by chitooligosaccharides with specific degrees of acetylation and polymerization[J]. CARBOHYDRATE POLYMERS,2012,89(2):511-518.
APA Wu, Haige.,Aam, Berit B..,Wang, Wenxia.,Norberg, Anne Line.,Sorlie, Morten.,...&杜昱光.(2012).Inhibition of angiogenesis by chitooligosaccharides with specific degrees of acetylation and polymerization.CARBOHYDRATE POLYMERS,89(2),511-518.
MLA Wu, Haige,et al."Inhibition of angiogenesis by chitooligosaccharides with specific degrees of acetylation and polymerization".CARBOHYDRATE POLYMERS 89.2(2012):511-518.
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