DICP OpenIR
学科主题物理化学
On-line measurement of propofol using membrane inlet ion mobility spectrometer
Zhou, Qinghua1,2; Wang, Weiguo1; Cang, Huaiwen1; Du, Yongzhai1,2; Han, Fenglei1,2; Chen, Chuang1,2; Cheng, Shasha1,2; Li, Jinghua1; Li, Haiyang1; Li HY(李海洋)
关键词Membrane Inlet Ion Mobility Spectrometer Propofol Exhaled Air
刊名TALANTA
2012-08-30
ISSN0039-9140
DOI10.1016/j.talanta.2012.07.001
98页:241-246
收录类别SCI
文章类型Article
部门归属1
项目归属102
产权排名1,1
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]DEGRADATION-PRODUCTS ; GAS ; WATER ; FEASIBILITY ; METABOLITES ; EXPLOSIVES ; ARTERIAL ; SURGERY ; PLASMA ; AIR
英文摘要The concentration of propofol in patient's exhaled air is an indicator of the anesthetic depth. In the present study, a membrane inlet ion mobility spectrometer (MI-IMS) was built for the on-line measurement of propofol. Compared with the direct sample introduction, the membrane inlet could eliminate the interference of moisture and improve the selectivity of propofol. Effects of membrane temperature and carrier gas flow rate on the sensitivity and response time have been investigated experimentally and theoretically. Under the optimized experimental conditions of membrane temperature 100 degrees C and carrier gas flow rate 200 mL min(-1), the calculated limit of detection (LOD) for propofol was 1 ppbv, and the calibration curve was linear in the range of 10-83 ppbv with a correlation coefficient (R-2) of 0.993. Finally, the propofol concentration in an anaesthetized mouse exhaled air was monitored continuously to demonstrate the capability of MI-IMS in the on-line measurement of propofol in real samples. (C) 2012 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000309327600035
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/118156
专题中国科学院大连化学物理研究所
通讯作者Li HY(李海洋)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Qinghua,Wang, Weiguo,Cang, Huaiwen,et al. On-line measurement of propofol using membrane inlet ion mobility spectrometer[J]. TALANTA,2012,98:241-246.
APA Zhou, Qinghua.,Wang, Weiguo.,Cang, Huaiwen.,Du, Yongzhai.,Han, Fenglei.,...&李海洋.(2012).On-line measurement of propofol using membrane inlet ion mobility spectrometer.TALANTA,98,241-246.
MLA Zhou, Qinghua,et al."On-line measurement of propofol using membrane inlet ion mobility spectrometer".TALANTA 98(2012):241-246.
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