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学科主题: 物理化学
题名: On-line measurement of propofol using membrane inlet ion mobility spectrometer
作者: Zhou, Qinghua1, 2;  Wang, Weiguo1;  Cang, Huaiwen1;  Du, Yongzhai1, 2;  Han, Fenglei1, 2;  Chen, Chuang1, 2;  Cheng, Shasha1, 2;  Li, Jinghua1;  Li, Haiyang1
通讯作者: 李海洋
关键词: Membrane inlet ;  Ion mobility spectrometer ;  Propofol ;  Exhaled air
刊名: TALANTA
发表日期: 2012-08-30
DOI: 10.1016/j.talanta.2012.07.001
卷: 98, 页:241-246
收录类别: SCI
文章类型: Article
部门归属: 1
项目归属: 102
产权排名: 1,1
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: The concentration of propofol in patient's exhaled air is an indicator of the anesthetic depth. In the present study, a membrane inlet ion mobility spectrometer (MI-IMS) was built for the on-line measurement of propofol. Compared with the direct sample introduction, the membrane inlet could eliminate the interference of moisture and improve the selectivity of propofol. Effects of membrane temperature and carrier gas flow rate on the sensitivity and response time have been investigated experimentally and theoretically. Under the optimized experimental conditions of membrane temperature 100 degrees C and carrier gas flow rate 200 mL min(-1), the calculated limit of detection (LOD) for propofol was 1 ppbv, and the calibration curve was linear in the range of 10-83 ppbv with a correlation coefficient (R-2) of 0.993. Finally, the propofol concentration in an anaesthetized mouse exhaled air was monitored continuously to demonstrate the capability of MI-IMS in the on-line measurement of propofol in real samples. (C) 2012 Elsevier B.V. All rights reserved.
关键词[WOS]: DEGRADATION-PRODUCTS ;  GAS ;  WATER ;  FEASIBILITY ;  METABOLITES ;  EXPLOSIVES ;  ARTERIAL ;  SURGERY ;  PLASMA ;  AIR
语种: 英语
WOS记录号: WOS:000309327600035
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/118156
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

Recommended Citation:
Zhou, Qinghua,Wang, Weiguo,Cang, Huaiwen,et al. On-line measurement of propofol using membrane inlet ion mobility spectrometer[J]. TALANTA,2012,98:241-246.
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