DICP OpenIR
Subject Area物理化学
On-line measurement of propofol using membrane inlet ion mobility spectrometer
Zhou, Qinghua1,2; Wang, Weiguo1; Cang, Huaiwen1; Du, Yongzhai1,2; Han, Fenglei1,2; Chen, Chuang1,2; Cheng, Shasha1,2; Li, Jinghua1; Li, Haiyang1; Li HY(李海洋)
KeywordMembrane Inlet Ion Mobility Spectrometer Propofol Exhaled Air
Source PublicationTALANTA
2012-08-30
ISSN0039-9140
DOI10.1016/j.talanta.2012.07.001
Volume98Pages:241-246
Indexed BySCI
SubtypeArticle
Department1
Funding Project102
Contribution Rank1,1
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordDEGRADATION-PRODUCTS ; GAS ; WATER ; FEASIBILITY ; METABOLITES ; EXPLOSIVES ; ARTERIAL ; SURGERY ; PLASMA ; AIR
AbstractThe concentration of propofol in patient's exhaled air is an indicator of the anesthetic depth. In the present study, a membrane inlet ion mobility spectrometer (MI-IMS) was built for the on-line measurement of propofol. Compared with the direct sample introduction, the membrane inlet could eliminate the interference of moisture and improve the selectivity of propofol. Effects of membrane temperature and carrier gas flow rate on the sensitivity and response time have been investigated experimentally and theoretically. Under the optimized experimental conditions of membrane temperature 100 degrees C and carrier gas flow rate 200 mL min(-1), the calculated limit of detection (LOD) for propofol was 1 ppbv, and the calibration curve was linear in the range of 10-83 ppbv with a correlation coefficient (R-2) of 0.993. Finally, the propofol concentration in an anaesthetized mouse exhaled air was monitored continuously to demonstrate the capability of MI-IMS in the on-line measurement of propofol in real samples. (C) 2012 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000309327600035
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/118156
Collection中国科学院大连化学物理研究所
Corresponding AuthorLi HY(李海洋)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Qinghua,Wang, Weiguo,Cang, Huaiwen,et al. On-line measurement of propofol using membrane inlet ion mobility spectrometer[J]. TALANTA,2012,98:241-246.
APA Zhou, Qinghua.,Wang, Weiguo.,Cang, Huaiwen.,Du, Yongzhai.,Han, Fenglei.,...&李海洋.(2012).On-line measurement of propofol using membrane inlet ion mobility spectrometer.TALANTA,98,241-246.
MLA Zhou, Qinghua,et al."On-line measurement of propofol using membrane inlet ion mobility spectrometer".TALANTA 98(2012):241-246.
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