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学科主题物理化学
Strong cation exchange column allow for symmetrical peak shape and increased sample loading in the separation of basic compounds
Long, Zhen; Wang, Chaoran; Guo, Zhimou; Zhang, Xiuli; Nordahl, Lilly; Liang, Xinmiao; Liang XM(梁鑫淼); Guo ZM(郭志谋)
关键词Scx Basic Compounds Symmetrical Peaks Load Amount Separation Efficiency
刊名JOURNAL OF CHROMATOGRAPHY A
2012-09-21
DOI10.1016/j.chroma.2012.07.008
1256页:67-71
收录类别SCI
文章类型Article
部门归属18
项目归属1803
产权排名1,1
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; REVERSED-PHASE CHROMATOGRAPHY ; ION CHROMATOGRAPHY ; STATIONARY PHASES ; DRUGS ; PH ; RETENTION ; SYSTEM ; ENRICHMENT ; ALKALOIDS
英文摘要Strong cation exchange (SCX) mode, an alternative to reversed-phase (RP) mode, was described in this paper to obtain symmetrical peak shape and high sample loading for the separation of basic compounds. The retention mechanisms on SCX modified silica sorbents have been demonstrated including electrostatic and hydrophobic interactions. The effects of eluent ionic strength, apparent pH on retention were investigated and the cation-exchange capacity was also characterized. Good efficiency (>56,000 plate m(-1)) and excellent peak shape (Tf < 1.2) for various basic probes were obtained on the SCX column. Furthermore, good peak shapes and separation can be maintained under high concentration injections, indicating good potential in preparative use. These results were also compared with those obtained on two conventional RP stationary phases. The overall results demonstrated that SCX stationary phases can be used as alternatives to RP stationary phases in the separation of basic compounds, especially in the purification of basic compounds. (c) 2012 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000308624000009
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/118161
专题中国科学院大连化学物理研究所
通讯作者Liang XM(梁鑫淼); Guo ZM(郭志谋)
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Nat Med, Key Lab Separat Sci Analyt Chem, Dalian 116023, Liaoning Provin, Peoples R China
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Long, Zhen,Wang, Chaoran,Guo, Zhimou,et al. Strong cation exchange column allow for symmetrical peak shape and increased sample loading in the separation of basic compounds[J]. JOURNAL OF CHROMATOGRAPHY A,2012,1256:67-71.
APA Long, Zhen.,Wang, Chaoran.,Guo, Zhimou.,Zhang, Xiuli.,Nordahl, Lilly.,...&郭志谋.(2012).Strong cation exchange column allow for symmetrical peak shape and increased sample loading in the separation of basic compounds.JOURNAL OF CHROMATOGRAPHY A,1256,67-71.
MLA Long, Zhen,et al."Strong cation exchange column allow for symmetrical peak shape and increased sample loading in the separation of basic compounds".JOURNAL OF CHROMATOGRAPHY A 1256(2012):67-71.
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