DICP OpenIR
Subject Area物理化学
A self-assembled polydopamine film on the surface of magnetic nanoparticles for specific capture of protein
Zhang, Min1,2; Zhang, Xihao1,2; He, Xiwen1,2; Chen, Langxing1,2; Zhang, Yukui1,2,3; Chen LX(陈朗星)
Source PublicationNANOSCALE
2012
DOI10.1039/c2nr30316g
Volume4Issue:10Pages:3141-3147
Indexed BySCI
SubtypeArticle
Department18
Funding Project1810
Contribution Rank3,5
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS KeywordMOLECULARLY IMPRINTED POLYMERS ; HISTIDINE-TAGGED PROTEINS ; IRON-OXIDE NANOPARTICLES ; BOVINE HEMOGLOBIN ; BIOMEDICAL APPLICATIONS ; SORBENT ASSAYS ; AQUEOUS-MEDIA ; HUMAN SERUM ; RECOGNITION ; SHELL
AbstractIn this study, we report a facile method for the preparation of core-shell magnetic molecularly imprinted polymers (MIPs) for protein recognition. Uniform carboxyl group functionalized Fe3O4 nanoparticles (NPs) were synthesized using a solvothermal method. Magnetic MIPs were synthesized by self-polymerization of dopamine in the presence of template protein on the surface of the Fe3O4 NPs. A thin layer of polydopamine can be coated on Fe3O4 NPs via dopamine self-polymerization and the imprinted polydopamine shells can be controlled by the mass ratio of Fe3O4 NPs and dopamine. More importantly, there is a critical value of polydopamine shell thickness for the maximum rebinding capacity. The as-prepared lysozyme-imprinted Fe3O4@polydopamine NPs show high binding capacity and acceptable specific recognition behavior towards template proteins. This method provides the possibility for the separation and enrichment of abundant proteins in proteomic analysis.
Language英语
WOS IDWOS:000303604000024
Citation statistics
Cited Times:195[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/118171
Collection中国科学院大连化学物理研究所
Corresponding AuthorChen LX(陈朗星)
Affiliation1.Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
2.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Min,Zhang, Xihao,He, Xiwen,et al. A self-assembled polydopamine film on the surface of magnetic nanoparticles for specific capture of protein[J]. NANOSCALE,2012,4(10):3141-3147.
APA Zhang, Min,Zhang, Xihao,He, Xiwen,Chen, Langxing,Zhang, Yukui,&陈朗星.(2012).A self-assembled polydopamine film on the surface of magnetic nanoparticles for specific capture of protein.NANOSCALE,4(10),3141-3147.
MLA Zhang, Min,et al."A self-assembled polydopamine film on the surface of magnetic nanoparticles for specific capture of protein".NANOSCALE 4.10(2012):3141-3147.
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