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学科主题: 物理化学
题名: A self-assembled polydopamine film on the surface of magnetic nanoparticles for specific capture of protein
作者: Zhang, Min1, 2;  Zhang, Xihao1, 2;  He, Xiwen1, 2;  Chen, Langxing1, 2;  Zhang, Yukui1, 2, 3
通讯作者: 陈朗星
刊名: NANOSCALE
发表日期: 2012
DOI: 10.1039/c2nr30316g
卷: 4, 期:10, 页:3141-3147
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1810
产权排名: 3,5
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Chemistry, Multidisciplinary ;  Nanoscience & Nanotechnology ;  Materials Science, Multidisciplinary ;  Physics, Applied
研究领域[WOS]: Chemistry ;  Science & Technology - Other Topics ;  Materials Science ;  Physics
英文摘要: In this study, we report a facile method for the preparation of core-shell magnetic molecularly imprinted polymers (MIPs) for protein recognition. Uniform carboxyl group functionalized Fe3O4 nanoparticles (NPs) were synthesized using a solvothermal method. Magnetic MIPs were synthesized by self-polymerization of dopamine in the presence of template protein on the surface of the Fe3O4 NPs. A thin layer of polydopamine can be coated on Fe3O4 NPs via dopamine self-polymerization and the imprinted polydopamine shells can be controlled by the mass ratio of Fe3O4 NPs and dopamine. More importantly, there is a critical value of polydopamine shell thickness for the maximum rebinding capacity. The as-prepared lysozyme-imprinted Fe3O4@polydopamine NPs show high binding capacity and acceptable specific recognition behavior towards template proteins. This method provides the possibility for the separation and enrichment of abundant proteins in proteomic analysis.
关键词[WOS]: MOLECULARLY IMPRINTED POLYMERS ;  HISTIDINE-TAGGED PROTEINS ;  IRON-OXIDE NANOPARTICLES ;  BOVINE HEMOGLOBIN ;  BIOMEDICAL APPLICATIONS ;  SORBENT ASSAYS ;  AQUEOUS-MEDIA ;  HUMAN SERUM ;  RECOGNITION ;  SHELL
语种: 英语
WOS记录号: WOS:000303604000024
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/118171
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
2.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China

Recommended Citation:
Zhang, Min,Zhang, Xihao,He, Xiwen,et al. A self-assembled polydopamine film on the surface of magnetic nanoparticles for specific capture of protein[J]. NANOSCALE,2012,4(10):3141-3147.
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